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Medicine possessing menacme accerant contraception action

A technology of action and medicine box, applied in the field of medicine box with the effect of promoting menstruation and contraception, can solve the problems of high failure rate, infection, injury, etc., and achieve the effect of good effect, small dose, and relieve anxiety and pain.

Inactive Publication Date: 2009-08-12
NAT RES INST FOR FAMILY PLANNING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most commonly used "menstrual reminder" method in many countries is to use a special suction cylinder-type negative pressure extractor. Although this method is safe and effective, it is still "invasive" because it needs to insert a catheter into the official cavity. May cause injury, lead to infection
Moreover, the failure rate of using suction cylinder negative pressure extraction is higher than that of traditional negative pressure suction.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0010] Materials and methods: A total of 720 women were recruited across the country, and their average expected postmenstrual prolongation was 4.9 days (±1.7). On the day of admission, 150 mg of mifepristone was given, and 36-48 hours later, the woman came to the outpatient clinic for vaginal placement of 400 micrograms of misoprostol, and stayed in the hospital for observation for one hour. Advise and follow up a case by regular visits to within 10 days after taking the medicine. The main observation indicators were pregnancy and menstrual cramps. Pregnancy is diagnosed by blood and urine hCG tests, ultrasonography, or expulsion of embryonic tissue. Simultaneous determination of serum estradiol and serum progesterone, the purpose is to analyze the cycle phase when menstruation is delayed, or early pregnancy.

[0011] Results: Only 1 case was lost to follow-up among 720 cases. Among the 719 cases, 492 cases were pregnant at the time of consultation, and 467 cases (95.0%) o...

Embodiment 1

[0014] Embodiment 1: tablet

[0015] Tablet I: compound mifepristone 150g, cornstarch 1000g, povidone 200g, stearin 100g, made into 1000 tablets. Tablet II: compound misoprostol 400mg, cornstarch 1000g, povidone 200g, stearin 100g, made into 1000 tablets. Packed in push-in packaging, made 1000 medicament boxes, each medicament box contains tablet I, tablet II each one.

[0016] Dosage: Menstruation delayed for 7 days or less, women who meet the medication standards, take tablet I on an empty stomach, fast for 2 hours after taking the medicine, after 36-48 hours, place tablet II in the posterior vaginal fornix, and lie flat on the bed for half a day Hours to ensure drug absorption, clinical observation for at least 1 hour, observe the bleeding rate, in case of possible side effects.

[0017] Adverse reactions: Some women may experience side effects such as nausea, vomiting, and uterine pain during treatment, and necessary treatment can be given symptomatically.

[0018] Co...

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PUM

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Abstract

To produce a medicament with a menstruating contraceptive effect, it consists of a sequential oral dosage unit of mifepristone followed by vaginal administration of a dosage unit of misoprostol 36-48 hours later. The invention is convenient to use, adopts oral and vaginal medication, and the dosage is small, the effect is good, the bleeding time is shorter than conventional medical abortion, and anxiety and pain can be relieved without any complication.

Description

field of invention [0001] The invention relates to a medicament, in particular to a medicament box with menstruation-inducing and contraceptive effects. Background technique [0002] Menstrual regulation refers to the use of drugs or devices to induce bleeding in women with delayed menstruation. Its use is mostly limited to within a week of menstrual delay, and menstruation induction can address a woman's concerns about an unwanted pregnancy, although she is not necessarily likely to become pregnant. In fact, the "menstruation reminder" of delayed menstruation also prevents many women from seeking abortion at a later time, especially in some countries where abortion is illegal, which saves women from the danger of unsafe abortion. The most commonly used "menstrual reminder" method in many countries is to use a special suction cylinder-type negative pressure extractor. Although this method is safe and effective, it is still "invasive" because it needs to insert a catheter in...

Claims

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Application Information

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IPC IPC(8): A61K31/5575A61K31/565A61K9/20A61P43/00A61P15/00A61P15/18
Inventor 肖碧莲
Owner NAT RES INST FOR FAMILY PLANNING
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