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Coating, coated articles and methods of manufacture thereof

A coating and coating technology, applied in coatings, prostheses, medical science, etc., can solve problems such as apatite-implant interface damage, and achieve good adhesion and good biological reactivity

Inactive Publication Date: 2009-07-22
美国英佛曼公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Apatite dissolution stops when the pH is no longer acidic; however, by this time the apatite-implant interface has been significantly disrupted

Method used

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  • Coating, coated articles and methods of manufacture thereof
  • Coating, coated articles and methods of manufacture thereof
  • Coating, coated articles and methods of manufacture thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] The substrate was Ti6Al4V available from Prudential Titanium Inc., MA. The metal substrate measures 1.0 inches in diameter by 0.125 inches in thickness and is grit blasted. The samples were coated with a TiN first layer using a PVD process at Ionbond Inc., NJ. The thickness of the first layer is about 4 microns.

[0097] The second layer contains stabilized silicate glass and nanoscale hydroxyapatite powder. The composition of the silicate glass is 67.8% SiO by weight 2 , 10.30 wt% B 2 o 3 , 8.30 wt% Na 2 O, 5.20 wt% Al 2 o 3 , 4.20 wt% K 2 O, 2.10 wt% LiO 2 , 1.05 wt% ZrO 2 , and 1.05 wt% TiO 2 . The glass is ground into a powder with a particle size of less than about 1.0 microns. Glass powder is stable in hot water, and its coefficient of thermal expansion is 7.8×10 -6 / °C. Nanoscale hydroxyapatite was synthesized by Inframat Corporation using chemical precipitation and autoclaving. The particle size of hydroxyapatite is about 30-50 nanometers. Hydro...

Embodiment 2

[0101] The substrate was Ti available from Prudential Titanium Inc., MA. The metal substrate measures 1.0 inches in diameter by 0.125 inches in thickness and is grit blasted. The samples were coated with a TiN first layer using a PVD process at Ionbond Inc., NJ. The thickness of the first layer is about 4 microns.

[0102] The second layer contains stabilized silicate glass and nanoscale hydroxyapatite powder. The composition of the silicate glass is 70.80% SiO by weight 2 , 9.30 wt% B 2 o 3 , 8.30 wt% Na 2 O, 5.20 wt% Al 2 o 3 , 2.20 wt% K 2 O, 2.10 wt% LiO 2 , 1.05 wt% ZrO 2 , and 1.05 wt% TiO 2 . The glass is ground into a powder with a particle size of less than about 1.0 microns. Glass powder is stable in hot water, and its coefficient of thermal expansion is 6.6×10 -6 / °C. Nanoscale hydroxyapatite was synthesized by Inframat Corporation using chemical precipitation and autoclaving. The particle size of hydroxyapatite is about 30-50 nanometers. Hydroxyapa...

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Abstract

A multilayer coating especially suitable for coating implants, such as orthopedic and dental implants, especially metallic implants. The first layer includes a bond coat of a dense material that is insoluble and inert in body fluids. The second layer includes apatite and a binder. The first layer protects the metal implant from corrosion, dissolution of the apatite, and interfacial reactions with the apatite and the adhesive. The apatite in this second layer is a bioactive agent that osseobonds the tissue. Through this adhesive, the coefficient of thermal expansion between the coating and the metal substrate can be adjusted. The multi-layer coating has a high bonding strength to the implant and at the same time has excellent bioactivity to the surrounding body tissue.

Description

[0001] Statement Regarding Federally Funded Research and Development [0002] This invention was made with support under grant number NIH1R43AR47278-02 awarded by the National Institutes of Health. Accordingly, the US Government has rights in this invention. field of invention [0003] This invention relates to apatite materials, and more particularly to coatings containing apatite. Background of the invention [0004] Synthetic apatites, including hydroxyapatite (HA), Ca 10 (PO 4 ) 6 (OH) 2 , fluoroapatite Ca 10 (PO 4 ) 6 f 2 , or hydroxyfluoroapatite Ca 10 (PO 4 ) 6 (OH) 2-x f x (x<1) has the same biological apatite (Ca 10-x (HPO 4 ) x (OH) 2- x ) similar composition, while bioapatite is the main component of hard tissues such as bone. Due at least in part to their excellent osteoconductivity, apatites are used as coatings on metallic implants or prostheses (eg, prosthetic hips) in biofixation. This apatite coating has two interfaces, one with the ti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/32A61L27/06A61L27/30
CPCA61L27/32A61L27/30
Inventor Z·张T·D·肖
Owner 美国英佛曼公司
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