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Premix plaster calcium phosphate bone cement

A calcium phosphate bone cement and premixing technology, which is applied in the field of biomedical bone tissue materials and premixed paste calcium phosphate bone cement, can solve the problems of wasting operation time, etc., achieve convenient production and use, low raw material cost, Ease of operation

Inactive Publication Date: 2008-10-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although calcium phosphate bioactive bone cement is an excellent material for bone repair, it is often necessary for the surgeon to temporarily mix its solid phase and liquid phase during clinical application, which not only wastes valuable operation time, but also affects implantation. The bone repair properties of the material have many potential adverse effects

Method used

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  • Premix plaster calcium phosphate bone cement
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Mix 0.55g of β-tricalcium phosphate and 0.45g of calcium dihydrogen phosphate monohydrate powder evenly as a premixed calcium phosphate bone cement powder, then mix the above bone cement powder with 0.37g of medical grade glycerin to make a viscous body, the viscous body was made into a Φ6mm×3mm sample through a mold and immersed in a PBS solution, placed in an environment of 37°C, and the average curing time was measured to be 18.4min. Fill the above-mentioned viscous body into a glass mold with openings at both ends of Φ10mm×8mm, and also immerse it in PBS solution and place it in an environment of 37°C and 100% humidity for 1 day and 7 days, and the average compressive strength is 7.5MPa and 7.5MPa respectively. 9.6 MPa.

Embodiment 2

[0020] Except for mixing 1 g of premixed bone cement powder with 0.333 g of medical grade glycerin, the rest of the preparation methods and processes refer to Example 1. The premixed calcium phosphate bone cement samples obtained in this example had an average curing time of 15.9 minutes, and the average compressive strengths after soaking in PBS solution for 1 day and 7 days were 8.6 MPa and 10.9 MPa, respectively.

Embodiment 3

[0022] Except for mixing 1 g of premixed bone cement powder with 0.303 g of medical grade glycerin, the rest of the preparation methods and processes refer to Example 1. The premixed calcium phosphate bone cement sample obtained in this example has an average curing time of 13.0 minutes, and the average compressive strengths after soaking in PBS solution for 1 day and 7 days are 10.3 MPa and 11.1 MPa, respectively.

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Abstract

The invention discloses a pre-mixing typed plaster calcium phosphate bone cement in the biological medical bone tissue material technology, which is characterized by the following: the solid powder and liquid powder with quality rate at 2.5-3.7: 1 are sealed container, the solid powder is beta-tricalcium phosphate and hydrated acid calcium phosphate with molar rate at 1:1, the liquid material is medical glycerin or polietilenglicol with molecular quantity at 400-800.

Description

technical field [0001] The invention relates to a premixed paste-like calcium phosphate bone cement, which belongs to the biomedical bone tissue material technology. Background technique [0002] Bone is a biocomposite material formed in vivo, a three-dimensional structure skillfully constructed by the precipitation of nanoscale apatite on the surface of collagen fibers. At present, clinically used repair and replacement materials for defective bone usually include autografts, allografts, xenografts, and various artificial biomaterials, such as synthetic polymer materials, metal materials, bioactive glass and ceramics, and Various composite materials, etc. However, these repair materials are more or less defective, the main reason is that they are in the number of donor sources, immune rejection, etc. or in mechanical stability and long-term biocompatibility and biocompatibility in the human body. There are also certain defects and deficiencies in degradability. [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/50
Inventor 尹玉姬韩冰姚康德
Owner TIANJIN UNIV
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