Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of bicychol in preparation of medicine for preventing and/or treating acute alcoholism and acute/chronic alcoholic liver injury

A technology for alcoholic liver injury and alcoholism, which can be used in drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., and can solve problems such as no record of bicyclic alcohol protective effect

Active Publication Date: 2008-01-30
BEIJING UNION PHARMA FACTORY
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there is no record of the protective effect of b

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of bicychol in preparation of medicine for preventing and/or treating acute alcoholism and acute/chronic alcoholic liver injury
  • Application of bicychol in preparation of medicine for preventing and/or treating acute alcoholism and acute/chronic alcoholic liver injury
  • Application of bicychol in preparation of medicine for preventing and/or treating acute alcoholism and acute/chronic alcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1. Effect of bicyclol on prolongation of sleep time in mice with acute ethanol poisoning

[0072]Male Kunming mice, weighing 22-24 grams, were randomly divided into 4 groups, 10 mice in each group, of which 3 groups were orally administered bicyclol 75, 150, 300 mg / kg in the afternoon of the first day of the experiment and the morning and afternoon of the next day. The control group was given the same volume of excipients. After fasting overnight, animals in each group were fed with 50% ethanol 16ml / kg. Observe the disappearance and recovery time of the righting reflex of the mice after oral administration of ethanol, and set the interval time as sleep closure.

[0073] The results showed that after oral administration of ethanol, the sleep time of the mice was as long as 3.6 hours, and both 150 and 300 mg / kg of bicyclol could significantly shorten the sleep time caused by ethanol, and showed a good dose-effect relationship, wherein the average sleep time of th...

Embodiment 2

[0074] Example 2. The effect of bicyclol on the death of mice caused by ethanol poisoning

[0075] Male Kunming mice, weighing 22-24 grams, were randomly divided into 4 groups, 10 mice in each group, of which 3 groups were orally administered bicyclol 100, 200, 300 mg / kg in the afternoon of the first day of the experiment and the morning and afternoon of the next day, and the control group Give the same volume of excipient. After the animals in each group were fasted overnight, 24 ml / kg of 50% ethanol was administered orally, and the number of animals that died 8, 12, and 24 hours after ethanol administration was recorded. The results are shown in Table 1. The mortality rates of the mice at 8, 12, and 24 hours after oral administration of ethanol were 60%, 80%, and 100%, respectively. Oral administration of bicyclol (200, 300mg / kg) can significantly reduce the mortality rate of ethanol poisoned mice.

[0076] Table 1 The effect of bicyclol on the death of mice caused by etha...

Embodiment 3

[0079] Example 3. Effect of bicyclol on ethanol-induced increase in serum ALT, liver TG, MDA and changes in GSH and GST in mice

[0080] Male Kunming mice, weighing 22-24 grams, were randomly divided into 5 groups, 10 mice in each group, of which 3 groups were orally administered bicyclol 75, 150, 300 mg / kg in the afternoon of the first day of the experiment and the morning and afternoon of the next day, and the control group Give the same volume of excipient. After the animals in each group were fasted overnight, except for the normal control group, the animals in the other groups were given 50% ethanol 12ml / kg, and the control group was given 20% glucose solution with the same energy. Animals were sacrificed 6 hours after ethanol administration, serum was taken to measure ALT, and liver was taken to measure the contents of TG, MDA, GSH and GST. As shown in Table 2, after oral administration of ethanol to mice, the liver TG increased to 1.3 times that of the normal control, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the use of the bicyclo alcohol having a general formula (I) in preparing medicament for preventing or treating acute alcoholic intoxication, acute and chronic alcoholic liver damage.

Description

technical field [0001] The invention relates to the application of bicyclol in the preparation of medicines for preventing or treating acute alcoholism and acute and chronic alcoholic liver damage. Background technique [0002] Alcoholic liver disease can be divided into alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis and alcoholic cirrhosis complicated by liver cancer according to its pathological changes. In recent years, with the improvement of people's living standards and the increase of alcohol consumption, alcoholic liver disease has gradually increased in our country, and it is currently the second largest liver disease after viral hepatitis. [0003] The exact pathogenesis of alcoholic liver disease is not yet fully understood. It is generally believed that the occurrence and development of alcoholic liver disease are closely related to the toxicity of alcohol and its metabolite acetaldehyde and the consequent disturbance of a series of physiologica...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/36A61K9/00A61P25/32A61P1/16
CPCA61K31/357A61P1/16A61P25/32A61P25/36
Inventor 李燕张纯贞刘耕陶李烨魏怀玲胡伟
Owner BEIJING UNION PHARMA FACTORY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com