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Application of (+) North America coptisine

A North American coptisine, application technology, applied in (10) North American coptisine use field, can solve the problems of difficulty in concentration, low blood-brain barrier passing rate, poor clinical effect, etc.

Inactive Publication Date: 2007-11-07
BEIJING LIANXIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A variety of neuropeptides and nerve growth factors have been considered to have the hope of treating dementia, but the clinical effect is not good, which may be mainly attributed to the difficulty of these substances entering the brain through the blood-brain barrier to exert their effects
After the advent of 2-pyrrolidone acetamide (trade name Naofukang), it is a new type of nootropic drug that has not been debated in the early literature. In recent years, it has been reported at home and abroad that the drug has a slight effect on various types of memory impairment and senile dementia. Or it is still inconclusive, it is a water-soluble compound, the blood-brain barrier pass rate is low, and it is not easy to concentrate on the target to play a role
(+) Coptisine in North America is already known (see Fang Qicheng, Lin Mao, Weng Qingmei, Zhu Chaode, Liu Xin. The Chemistry of Corydalis Plant Alkaloids——Chemical Research on Four Corydalis Plant Alkaloids in Qinghai Plateau. Acta Pharmaceutica Sinica, 1981 , 16(10):798-800.), but the research on its biological activity has not been reported so far

Method used

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  • Application of (+) North America coptisine
  • Application of (+) North America coptisine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 (+) Coptisine from North America acts on the memory acquisition disorder caused by scopolamine (avoiding the dark method)

[0042] 50 Kunming mice were randomly divided into 5 groups: normal control group, scopolamine-damaged memory model group, (+) coptisine 0.075mg / kg, 0.15mg / kg, 0.30mg / kg three dose groups. Compared with the normal control group, after intraperitoneal injection of scopolamine 1.0mg / kg, the percentage of errors reached 60%, and the latency period was shortened by 90 seconds. Compared with the control group, the difference was significant, suggesting that scopolamine can significantly destroy the learning and memory acquisition of animals. After pre-peritoneal administration of (+) Coptisine, the training was carried out, and the test was repeated 24 hours later. The results are shown in Table 1

[0043] group

dosage

Number of errors

Latency (seconds)

mistake%

normal control group

SCOP

HDST+SCOP ...

Embodiment 2

[0046] Embodiment 2 (+) Coptisine of North America causes the effect of memory acquisition disorder on pentobarbital sodium (avoiding the dark method)

[0047] 60 Kunming mice were randomly divided into 6 groups: normal control group, pentobarbital sodium damage memory model group, tacrine group, (+) berberine 0.075mg / kg, 0.15mg / kg, 0.30mg / kg kg three dose groups. Subcutaneous injection of pentobarbital sodium 25mg / kg can obviously destroy the learning and memory ability of animals, the latency period is shortened from 275.8 seconds to 65.9 seconds, and the percentage of errors increases from 10% to 90%. The results are shown in Table 2

[0048] group

dosage

Number of errors

Latency (seconds)

mistake%

control group

PTB

Tac+PTB

HDST+PTB

HDST+PTB

HDST+PTB

25

1.5+25

0.075+25

0.15+25

0.30+25

0.1±0.3

1.4±1.0 ++

1.3±0.7

1.1±0.8

0.4±0.5*

0.6±0.5*

275.8±69.6

65.9±8...

Embodiment 3

[0051] Embodiment 3 (+) Coptisine from North America affects learning and memory impairment caused by sodium pentobarbital (water maze test)

[0052] 60 Kunming mice were randomly divided into 6 groups: normal control group, intraperitoneal injection of pentobarbital sodium 15mg / kg destroying memory model group, Nimodipine (NMDP) group, (+) Coptisine oral administration of 2.5mg / kg, 1.25mg / kg, 0.625mg / kg three dose groups (respectively 1 / 10, 1 / 20, 1 / 40 of the median lethal dose). The experimental results showed that pentobarbital sodium 15mg / kg destroyed the learning and memory ability of the mice, and the time to swim to the safe platform was 1 / 3 longer than that of the control group (12.2 seconds), which was 18.0 seconds, and the difference was significant (P< 0.05). The number of mistakes was 2.4, which was increased compared with the control group (1.7 times), but the statistical difference was not significant. The results are shown in Table 3

[0053] group ...

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Abstract

The present invention relates to the application purify (+)-hydrastine in preparing medicine for preventing and treating dementia, promoting intelligence growth and raising oxygen lack resistance. Animal experiment shows that (+)-hydrastine can raise the learning memory of model mouse with dementia caused by scopolamine and pentobarbital sodium, raise the learning memory of health mouse and aged mouse and prolong the time of mouse in oxygen lack survival. The (+)-hydrastine has high activity and low toxicity.

Description

technical field [0001] The invention relates to the application of (+) berberine in the preparation of medicines for preventing and treating dementia, promoting intelligence and improving hypoxia tolerance. It has been confirmed by animal experiments that (+) berberine can improve the learning and memory ability of dementia model mice induced by scopolamine and pentobarbital sodium, improve the learning and memory ability of normal mice and aged mice, and improve the survival of hypoxic mice time. (+) Coptisine has the advantages of high activity and low toxicity in therapeutic doses. Background technique [0002] At present, the average life expectancy of our population has exceeded 70 years. A foreign scientific study predicts that by 2025, the elderly aged 65 and over will reach 18.8%. This figure shows that in more than 20 years, there will be one elderly person in every five people. Alzheimer's Disease (Alzheimer's Disease) mostly occurs in more than 50 years old. M...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4355A61P25/28A61P43/00
Inventor 黄俊华
Owner BEIJING LIANXIN PHARMA CO LTD
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