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Methods and compositions for expanding, identifying, characterizing and enhancing potency of mammalian-derived glial restricted progenitor cells

a technology of restricted progenitor cells and compositions, which is applied in the field of methods and compositions for expanding, identifying, characterizing and enhancing the potency of mammalian-derived glial restricted progenitor cells, can solve the problems of reducing the number of glial scar formation, the inability of demyelinated neurons to properly conduct signals, and the inability to develop products that can help restore lost function, so as to reduce the formation of glial scars

Inactive Publication Date: 2019-01-31
Q THERAPEUTICS
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Problems solved by technology

Demyelinated neurons cannot properly conduct signals and eventually will die.
However, the majority of patients who experience demyelination due to various diseases or trauma do not experience sufficient endogenous remyelination (Prineas et al., Ann. Neurol. 1993 33:137-151), and despite much need and effort, little progress has been made in developing products that can help restore lost function.

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  • Methods and compositions for expanding, identifying, characterizing and enhancing potency of mammalian-derived glial restricted progenitor cells
  • Methods and compositions for expanding, identifying, characterizing and enhancing potency of mammalian-derived glial restricted progenitor cells
  • Methods and compositions for expanding, identifying, characterizing and enhancing potency of mammalian-derived glial restricted progenitor cells

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Embodiment Construction

[0021]The present invention provides methods for manufacturing mammalian glial progenitor cells (GRPs). GRPs are also referred to as glial restricted precursor cells or glial progenitor cells in the literature.

[0022]Mammalian GRP cells of the present invention can be derived from any mammalian tissue source capable of generating A2B5 positive cells. Examples of such mammalian tissue sources include, without limitation, embryonic / fetal, and adult (inclusive of all ages after birth) sources, all from tissues including, but not limited to neural, brain, spinal cord, optic nerve, olfactory epithelium, endocrine, skin, muscle, fat, connective, placental, cord blood, blood, bone marrow, bone, embryonic stem cells, and induced pluripotent cells. By capable of generating A2B5 positive cells it is meant to include mammalian tissue sources differentiated into A2B5 positive cells, mammalian tissue sources de-differentiated into A2B5 positive cells, as well as mammalian tissue sources de-differ...

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Abstract

Methods for producing a population of human-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended or undesired cellular phenotypes and / or decreased standard deviation in the cells of the population are provided. Also provided are antibody panels and gene expression profiles to characterize GRPs and a method for its use in characterizing GRP cells. In addition methods for use of these GRP cells to generate astrocytes and / or oligodendrocytes, to re-myelinate neurons and to treat glial cell related and other neurodegenerative diseases or disorders or injuries or damage to the nervous system are provided. A method to manufacture neural cells depleted of A2B5 positive cells is also provided.

Description

[0001]This patent application is a continuation of U.S. Ser. No. 13 / 508,803 filed May 9, 2012, which is the National Stage of International Application No. PCT / US2010 / 055956, filed Nov. 9, 2010, which claims the benefit of priority from U.S. Provisional Application Ser. No. 61 / 326,799, filed Apr. 22, 2010 and U.S. Provisional Application Ser. No. 61 / 260,441, filed Nov. 12, 2009, teachings of each of which are herein incorporated by reference in their entireties.INTRODUCTIONField of the Invention[0002]The present invention provides manufacturing methods for a population of mammalian-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended cellular phenotypes and / or decreased standard deviation in the cells of the population as well as methods for use of these cells. Also provided in the present invention is an antibody panel to characterize GRPs and a method for its use in characterizing GRP cells.Background of the Invention[0003]Glial restricted progeni...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N5/079
CPCC12N5/0622A61K35/30C07K16/18C12N5/0081C12N5/0602C12N5/0618C12N5/0623G01N33/56966A61P25/00A61P25/28A61P43/00
Inventor SANDROCK, ROBERTCAMPANELLI, JAMESEPPSTEIN, DEBORAH
Owner Q THERAPEUTICS
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