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Topical delivery of l-arginine to cause beneficial effects

a technology of l-arginine and beneficial effects, which is applied in the direction of drug compositions, peptide/protein ingredients, hair cosmetics, etc., can solve the problems of erectile failure (impotence), impaired blood flow to the penis, and many investigators have failed to show such an effect, etc., to achieve high ionic strength, improve absorption of active agents, and high hydrophobic

Inactive Publication Date: 2010-12-16
STRATEGIC SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Though the suggestion has been made that minoxidil operates through increase in the blood supply to the scalp, many investigators have failed to show such an effect.
It has long been recognized that impaired blood flow to the penis is a major cause of erectile failure (impotence) in men.
The results were inconclusive and the treatment not well tolerated because of the cardiac response to nitroglycerine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020]In this example a 53 year old man with a scalp lacking sufficient hair consisting of a severely receding hairline as well as large “bald spot” on the top rear of his head was provided with a penetrating cream containing L-arginine hydrochloride (12.5% w / v), choline chloride (10% w / v), sodium chloride (5% w / v) and magnesium chloride (5% w / v). The cream was applied to the bald areas each night before going to bed and was rubbed in extensively for maximal absorption. New hair growth was noted within 2-3 weeks. Within 4 months the receding hairline (previously 4 cm of bald skin) had returned to normal and the “bald spot” previously more than 7 cm in diameter had been reduced to an area of less than 2 cm with even this area showing some new hair growth.

example 2

[0021]In a 54 year old man with a history of impotence twice daily administration of a penetrating cream containing L-arginine hydrochloride (12.5% w / v), choline chloride (10% w / v), sodium chloride (10% w / v) and magnesium chloride (5% w / v) directly to the penis twice daily for 7 days brought initial relief from the symptoms of impotence and allowed the subject to resume normal sexual activity. This relief of symptoms was maintained by continuation of the treatment daily.

example 3

[0022]In a 62 year old man with a history of impotence placed a condom containing a water based penetrating cream containing L-arginine hydrochloride (12.5% w / v), choline chloride (10% w / v), sodium chloride (5% w / v) and magnesium chloride (5% w / v) was warn on the flaccid penis for 30-60 minutes before erection was desired. At that time, when sexual performance was needed, an erection was easily obtained and normal sexual activity was conducted.

[0023]Accordingly, it can be seen that in the present invention I have provided agents, which when applied to scalp lacking sufficient hair causes hair growth through utilization of one of the body's own mechanisms. This effect is achieved by providing the biochemical substrate at the local site from which nitric oxide is produced. Nitric oxide causes increased local blood flow, which enables the growth of hair. Further I have provided agents which when applied to leg ulcers cause healing through use of the body's own mechanisms. Still further...

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Abstract

The application of L-arginine and its derivatives to the skin causes beneficial effects of wound healing, increasing erectile function and increased growth of hair when applied in sufficient quantity to the skin. A hostile biophysical agent may be combined with the L-arginine to increase its absorption into the skin. The desired concentrations of the hostile biophysical agent is increased when concentration of L-arginine is less than 20% of the concentration of the substance applied to maximize its effect.

Description

BACKGROUND[0001]1. Field of the Invention[0002]This invention relates to topical application of a cream, gel, or other vehicle which contains substances such as L-arginine which delivers these substances into tissue for the purpose of producing beneficial effects such as growth of hair on the scalp, healing of leg ulcers secondary to diabetes or confinement to bed and overcoming erectile dysfunction, as well as beneficial effects through restoration of natural mechanisms based on improvement of local blood supply.[0003]2. Prior Art[0004]Approaches to improving local blood flow have been many and consist of both systemic and topical approaches. Many beneficial effects could be obtained should improvement in local blood flow be achieved since impairment of local blood flow causes a variety of negative consequences.[0005]It has been recognized that deficiencies in blood flow in the scalp occur in male pattern baldness. See G. Duplecnain et al., J. Louisiana State Med. Soc. 146, 7, (199...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/198A61K31/223A61K36/81A61P17/14A61P17/02A61P15/00A61K8/02A61K8/14A61K8/44A61Q7/00A61Q19/00
CPCA61K8/0208A61K8/14A61K8/44A61K31/198A61Q7/00A61Q19/00A61P15/00A61P15/10A61P17/02A61P17/14A61P9/08
Inventor FOSSEL, ERIC T.
Owner STRATEGIC SCI & TECH
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