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Aldehyde dehydrogenase inhibitors as novel depigmenting agents

a technology of aldehyde dehydrogenase and inhibitors, which is applied in the field of hyperpigmentary skin disorders, can solve the problems of poorly understood spectrum of gene products participating in melanogenesis in different physiological niches, and achieve the effect of reducing skin pigmentation and skin pigmentation

Inactive Publication Date: 2010-09-09
RGT UNIV OF CALIFORNIA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0005]In certain embodiments, the invention provides a method for reducing skin pigmentation, the method comprising topically administering an effective amount of an inhibitor of aldehyde dehydrogenase to pigmented skin of a subject. In variations of such embodiments, the aldehyde dehydrogenase inhibitor includes disulfuram, cyanamide, or a derivative of either. In illustrative embodiments, the skin pigmentation includes hyperpigmentation, such as that due to sun exposure, inflammation, chemical exposure and/or skin trauma. Subjects amenable to...

Problems solved by technology

Much of the core synthetic machinery driving melanin production has been identified, however, the spectrum of gene products participating in melanogenesis in different physiological niches is poorly understood.

Method used

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  • Aldehyde dehydrogenase inhibitors as novel depigmenting agents
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  • Aldehyde dehydrogenase inhibitors as novel depigmenting agents

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Genome-wide siRNAi-Based Functional Genomics of Pigmentation Identifies Novel Regulatory Networks Governing Melanogenesis in Human Cells

Abstract

[0047]RNA-mediated interference (RNAi)-based functional genomics provides the opportunity to derive unbiased comprehensive collections of pharmaceutically tractable single gene targets supporting melanin production. In this study, we have combined a high-throughput cell-based one-well / one-gene screening platform with a genome-wide arrayed synthetic library of chemically synthesized small interfering RNAs to identify novel biological pathways that govern melanin biogenesis in human melanocytes. 94 novel genes that support pigment production were identified with a low false discovery rate. Secondary validation and mechanistic studies identified a large panel of targets that converge on tyrosinase expression and stability. Small molecule inhibition of a family of gene products in this class was sufficient to impair chronic tyrosinase expression...

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Abstract

The present invention provides methods and compositions for reducing pigmentation.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to and benefit of U.S. Ser. No. 61 / 100,989, filed on Sep. 29, 2008, as provided for under 35 U.S.C. §119 and / or 35 U.S.C. §120, as appropriate. U.S. Ser. No. 61 / 100,989 is incorporated herein by reference, in its entirety, for all purposes.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT[0002]This invention was made with government support under NIH grant no. CA71443, National Cancer Institute grant no. P30CA62203, Laser Microbeam Program grant no. P41-RR01192, and DoD grant no. W81XWH060749. The Government has certain rights in the invention.FIELD OF THE INVENTION[0003]The present invention relates to generally to the treatment of hyperpigmentary skin disorders. In particular, the invention relates to methods and compositions for treating such disorders.BACKGROUND OF THE INVENTION[0004]Melanin protects the skin and eyes from the harmful effects of UV irradiation...

Claims

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Application Information

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IPC IPC(8): A61K31/27A61K31/16A61P17/00
CPCA61K31/27A61K31/145A61K31/275A61K8/46A61K31/16A61Q19/02A61K8/40A61K8/41A61K31/26A61P17/00A61K8/42A61K47/16
Inventor GANESAN, ANANDWHITE, MICHAEL A.FARMER, PATRICK J.
Owner RGT UNIV OF CALIFORNIA
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