Method for determining susceptibility of tumor to treatment with anti-neoplastic agent

Abstract

Determining the level of one or more glucose transporters in a sample containing cancer cells and comparing the levels to a reference value to determine whether the cancer is sensitive to treatment with an anticancer agent comprising Glucose or glucose analogs that can be transported into cancer cells by glucose transporters.

Description

[0001] Cross reference to related patent applications [0001] This application claims the rights and interests of the U.S. Provisional Application 60 / 453,083 filed on March 7, 2003, the entire contents of which are incorporated herein for reference. Technical field [0002] The present invention relates to a method for determining the sensitivity of tumors to treatment with anti-tumor agents, and has applications in biology and medicine. Background technique [0003] The term "cancer" generally refers to one of more than 100 diseases caused by the uncontrolled growth and dissemination of abnormal cells. It can be solid tumors, lymphomas and non- Non-solid cancers are in the form of leukemia. Doctors who treat cancer patients have a variety of drug therapies and non-drug therapies to choose from. However, determining the appropriate therapy for a specific patient is problematic. The reason is that although certain treatments can be matched to certain cancer types, the patient's res...

AI Technical Summary

Problems solved by technology

However, determining the appropriate therapy for a specific patient can be problematic because, while certain treatments can be matched to certain cancer types, patients respond inconsistently to a particular treatment