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Dialyser and its producing method

A dialyzer and hollow technology, applied in the field of dialyzers, can solve the problems such as the inability to increase the internal filtration volume and the internal reverse filtration volume of the dialyzer, and the inability to sufficiently reduce the volume of the dialysate flow path, so as to increase the internal filtration volume and internal reverse filtration volume. Filtration volume, easy-to-manufacture effect

Active Publication Date: 2004-07-14
NIPRO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The elastic tube used to compress the hollow fiber bundle of this invention cannot sufficiently reduce the volume of the dialysate flow path, and cannot achieve the purpose of increasing the internal filtration volume and internal reverse filtration volume of the dialyzer to improve the dialysis efficiency

Method used

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  • Dialyser and its producing method
  • Dialyser and its producing method
  • Dialyser and its producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The lumen of the flanged elastic tube made of silicone with an inner diameter of 28.5 mm, an outer diameter of 36 mm, a length of 20 mm (L / M = about 7.35%), and an outer diameter of the flange part of 37.5 is performed with a jig with a vacuum suction function. To expand the diameter, a hollow fiber bundle is inserted into the lumen. The bundle is obtained by bundling approximately 9,000 hollow fiber membranes made of polyethersulfone with an inner diameter of 200 μm and an outer diameter of 280 μm. After insertion, the diameter expansion of the elastic tube is released. Next, the elastic tube having the hollow fiber bundle inserted therein was inserted into the central part of a dialyzer case body made of polycarbonate having a total length of 272 mm and an inner diameter of 36.5 mm. In this embodiment, the housing main body and the elastic tube are pre-coated with glycerin as a lubricant on the inner wall of the housing main body and the outer peripheral surface of the...

Embodiment 2

[0094] As the elastic tube, except for using a flanged elastic tube made of silicone with an inner diameter of 28.5 mm, an outer diameter of 36 mm, a length of 40 mm (L / M=about 14.71%), and an outer diameter of the flange portion of 37.5 mm, the other is the same as that of the embodiment. 1 The same operation is performed to manufacture the dialyzer. The filling rate of the hollow fiber membrane in the lumen of the elastic tube in this dialyzer was 79%.

Embodiment 3

[0096] As the elastic tube, except for using an elastic tube with a flange made of silicone with an inner diameter of 28.5 mm, an outer diameter of 36 mm, a length of 60 mm (L / M=about 22.06%), and an outer diameter of the flange portion of 37.5 mm, the other is the same as in the embodiment. 1 The same operation is performed to manufacture the dialyzer. The filling rate of the hollow fiber membrane in the lumen of the elastic tube in this dialyzer was 79%.

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Abstract

A dialyzer including a substantially cylindrical case 2, a hollow fiber bundle 3 made of a plurality of hollow fiber membranes provided in the case 2, a blood flow path formed by lumens of the hollow fiber membranes, a dialysate flow path formed by a gap between the inner wall of the case 2 and the hollow fiber membranes, and a cylindrical elastic tube 4 inserted in the gap between the inner wall of the case 2 and the hollow fiber bundle 3.

Description

technical field [0001] The present invention relates to dialyzers for use in dialysis therapy, and more particularly to internal filtration-promoted dialyzers capable of increasing internal filtration flow and internal reverse filtration flow within the dialyzer. Background technique [0002] Conventionally, blood purification treatment such as hemodialysis or hemodiafiltration has been performed in order to treat patients with impaired renal function, for example, renal insufficiency, etc., in which the waste removal function in the blood is impaired. In this blood purification treatment, blood is brought into contact with a dialysate through a semipermeable membrane in a dialyzer, and urea, creatinine, uric acid, low-molecular-weight proteins, water, and the like accumulated in the blood are removed. [0003] In recent years, the causative substance of amyloidosis, one of the complications of dialysis treatment, has been identified as β with a molecular weight of 11,800 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16A61M1/18A61M1/34B01D61/28B01D61/30B01D63/02B01D65/00B01D65/02
CPCB01D65/02B01D61/30A61M2001/3465B01D2313/23B01D2321/04A61M2001/3427B01D63/021B01D65/00A61M2001/1627A61M1/16B01D63/02A61M1/1627A61M1/3427A61M1/3465B01D63/0233B01D63/034
Inventor 春原隆司安保秀彦增田利明
Owner NIPRO CORP
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