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Method of treating peripheral vascular diseases, peripheral neuropathies, and automatic neuropathies

A technology for peripheral vascular disease and neuropathy, applied in cardiovascular system diseases, skin diseases, sensory diseases, etc., can solve the problems of unreported interest or concern of cGMPPDE5 inhibitors

Inactive Publication Date: 2003-09-03
PFIZER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no interest or concern has been reported regarding cGMP PDE5 inhibitors in the management of diabetic foot ulcers

Method used

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Examples

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Embodiment

[0028] Patient No. 1 was an insulin-dependent diabetic who had suffered from erectile dysfunction and subsequently suffered from a diabetic foot ulcer. During the treatment of erectile dysfunction, healed foot ulcers were noted. This foot ulcer started about 2 years ago and the patient has had vascular studies, seen a vascular doctor, a podiatrist, and at best and only minimally effective in a trauma care clinic. He was also hospitalized for about 1 month on IV antibiotics, etc., and there was a very real threat that the patient would need amputation below the knee. Ulcers sometimes appear to heal, but only return to their pre-treated size and depth. Once sildenafil was started for his erectile dysfunction, a reduction in size of the ulcer was noted and the patient was instructed to start taking 50 mg of sildenafil once a day. The diabetic foot ulcer thus completely resolved within one month, and the patient continued the treatment for the next 2 years without recurrence.

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PUM

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Abstract

The invention relates to a method of treating a patient suffering from peripheral vascular disease, peripheral neuropathies, or autonomic neuropathies by administering a cGMP PDE5 inhibitor such as sildenafil. The method is particularly applicable to patients suffering from diabetic foot ulcers, Raynaud's Phenomenon, CREST Syndrome, erythromatosis, rheumatoid diseases, diabetic retinopathies and onychiomycosis. According to the present invention, a cGMP PDE5 inhibitor may be administered as a prophylactic to patients predisposed to develop a peripheral vascular disease, peripheral neuropathy or autonomic neuropathy.

Description

[0001] Cross-Referenced Related Applications [0002] This application claims priority to U.S. Provisional Application No. 60 / 215,065 (filed June 30, 2000) and U.S. Provisional Application No. 60 / 219,029 (filed July 18, 2000), both entitled "Treatment of Diabetic Ulcers" method", the contents of which are hereby incorporated by reference in their entirety. field of invention [0003] The present invention relates to 3', 5'-cyclic guanosine monophosphate type V (cGMP PDE5) inhibitors (including the compound sildenafil) in diseases related to peripheral vascular disease, peripheral neuropathy, autonomic neuropathy, especially related to diabetes Use in the treatment of disease. Background of the invention [0004] The diseases associated with peripheral vascular disease and autonomic neuropathy are diverse but the chronic pathology is consistent and difficult to cure. Many of these diseases are associated with diabetes. Although it is not well known whether other such disea...

Claims

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Application Information

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IPC IPC(8): C07D487/04A61K31/495A61K31/519A61K45/00A61P9/00A61P9/08A61P17/02A61P25/00A61P25/02A61P27/02A61P29/00A61P31/10
CPCA61K31/495A61P17/02A61P25/00A61P25/02A61P27/02A61P29/00A61P31/10A61P9/00A61P9/08
Inventor R·E·伍德
Owner PFIZER INC
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