Oral cavity adhesive plaster composition for curing gingival disease, laryngopharyngitis and halitosis
A technology for pharyngitis and composition, which is applied in the field of drugs for treating oral diseases, can solve the problems of not being able to maintain a long enough antibacterial effective time in the oral cavity, and achieve the effects of simple preparation, periodontitis treatment, and convenient use
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Embodiment 1
[0020] Each tablet weighs 200mg, and the formula is as follows:
[0021] Chlorhexidine 5mg
[0022] Carbopol 60mg
[0023] Cyclodextrin 72mg
[0024] Dipeptide sugar 1.3mg
[0025] Dextrin 60mg
[0026] Eucalyptus Peppermint Oil 0.70mg.
[0027] Magnesium Stearate 1.0mg
[0028] Coat eucalyptus mint oil with cyclodextrin, mix it with other above-mentioned materials evenly, add magnesium stearate after wet granulation, and press into tablets with a 10mm punch to obtain the product. Each tablet contains 5mg of chlorhexidine.
Embodiment 2
[0030] Each tablet weighs 200mg, and the formula is as follows:
[0031] Dumephen 0.5mg
[0032] Hypromellose 120mg
[0033] Dipeptide sugar 2.5mg
[0034] Dextrin 70mg
[0035] Talc powder 7.0mg
[0036] After mixing the above materials evenly, dry granulate, add talcum powder, press with a 10mm punch, and each tablet contains 0.5mg of the main drug.
Embodiment 3
[0038] In vitro drug release of chlorhexidine oral adhesive tablet:
[0039] Adopt basket method, medium is 900ml distilled water, 37 ℃, 50RPM, take samples at different time, measure and release drug, the result is shown in the table. It shows that the present invention can release medicine continuously for 3-4 hours.
[0040] Release time (h)
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Abstract
Description
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Application Information
![application no application](https://static-eureka-patsnap-com.libproxy1.nus.edu.sg/ssr/23.2.0/_nuxt/application.06fe782c.png)
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