Tympanic membrane repair stent material, preparation method and preparation method of tympanic membrane repair stent

A stent material and tympanic membrane technology, applied in the field of materials, can solve the problems such as the large difference between the acoustic properties and the mechanical properties of the natural tympanic membrane structure, the inability to achieve the tympanic membrane vibration properties, and the easy failure of surgical treatment, so as to achieve individualized parameter regulation and convenience. Effects of cell attachment growth, excellent deformation resistance

Pending Publication Date: 2022-04-08
TSINGHUA UNIV +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cartilage, perichondrium, and temporalis fascia are often used as scaffolds in clinical operations to repair tympanic membrane perforation, but they are all quite different from the natural tympanic membrane in terms of acoustic and mechanical properties, and cannot reach the normal vibration characteristics of the tympanic membrane.
The mechanical properties of the tympanic membrane after cartilage plate repair are close to those of the normal tympanic membrane, but due to its own characteristics, its acoustic performance is significantly reduced; the temporal muscle fascia has similar acoustic properties to the tympanic membrane, but its mechanical properties are significantly different from the normal tympanic membrane
In addition, the inside and outside of the perforated graft in tympanoplasty are exposed to the air, and only the periphery of the graft is in contact with human tissue, and there are no well-known nutrient vessels, and improper operation is prone to failure
If the graft does not survive, it needs to be re-operated, which brings great physical and mental pain and economic burden to the patient, and causes a certain degree of social burden

Method used

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  • Tympanic membrane repair stent material, preparation method and preparation method of tympanic membrane repair stent
  • Tympanic membrane repair stent material, preparation method and preparation method of tympanic membrane repair stent
  • Tympanic membrane repair stent material, preparation method and preparation method of tympanic membrane repair stent

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preparation example Construction

[0046] In the second aspect, the present invention provides a method for preparing the tympanic membrane repair stent material described in the first aspect above, the method comprising: using electrostatic fusion direct writing technology to melt biodegradable materials, stacking and spinning to form uniform pores, And layered fiber webs stacked between layers.

[0047] Wherein, the biodegradable material is any one of polylactic acid, lactic acid / glycolic acid copolymer and polycaprolactone;

[0048] The pores are regular polygons.

[0049] During specific implementation, the preparation method of the tympanic membrane repair stent material provided by the present invention effectively improves the uniformity of repeated stacking of fiber filaments between layers during the spinning process by applying the electrostatic fusion direct writing technology to the preparation of the tympanic membrane repair stent material. The pore shape and size of the layered fiber net stacked...

Embodiment 1

[0058] Using a bioscaffold printer with an electromelt spinning module, a virtual specific shape is first drawn on the print bed by computer software, such as figure 1 shown. preparation figure 1 In the structural form, the high molecular polymer is placed in the collection barrel, and the high molecular polymer is turned into a molten state by heating. The diameter of the nozzle of the collection barrel is 250 microns, the distance from the nozzle to the printing bed is 2.5mm, and a voltage of 8.15kv is applied Prepare 15-micron fibers, form a stable low-velocity molten jet by applying a voltage between the nozzle and the print bed, and directly print the molten polymer on the print bed, which is formed by sequential and consistent stack printing figure 1 The interlayer (4 layers) stacked layered web structure is shown.

[0059] The mechanical properties of the prepared layer (4-layer) fiber web were tested by DMA dynamic mechanics experiment, uniaxial tensile experiment an...

Embodiment 2

[0063] Using a bioscaffold printer with an electromelt spinning module, first draw on the print bed by computer software such as figure 2 As shown in the dummy specific shape, the preparation figure 2 In the structural form, the high molecular polymer is placed in the collection barrel, and the high molecular polymer is turned into a molten state by heating. The diameter of the nozzle of the collection barrel is 250 microns, the distance from the nozzle to the printing bed is 2.5mm, and a voltage of 8.15kv is applied Prepare 20-micron fibers, form a stable low-velocity molten jet by applying a voltage between the nozzle and the print bed, and directly print the molten polymer on the print bed, which is formed by sequential and consistent stack printing figure 2 The interlayer (3 layers) stacked layered web structure is shown.

[0064] The mechanical properties of the prepared layer (4-layer) fiber web were tested by DMA dynamic mechanics experiment, uniaxial tensile experi...

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Abstract

The invention provides a tympanic membrane repair stent material, a preparation method and a preparation method of a tympanic membrane repair stent. The tympanic membrane repair stent material is a layered fiber net which is made of biodegradable materials, has consistent pores and is stacked between layers; wherein the biodegradable material is any one of polylactic acid, a lactic acid/glycollic acid copolymer and polycaprolactone; and the pores are regular polygons. According to the preparation method, the electrostatic melting direct writing technology is applied to preparation of the tympanic membrane repair stent material, so that the consistency of repeated stacking of fiber yarns between layers in the spinning process is effectively improved, the pore shape and size uniformity of layered fiber nets stacked between the layers are kept, and the qualification rate of preparation of the tympanic membrane repair stent material is increased. Besides, the electrostatic melting direct writing technology can realize micron-sized accurate manufacturing, so that technical support is provided for manufacturing an accurate artificial tympanic membrane stent, and hope is brought to accurate repair of vast tympanic membrane perforation patients.

Description

technical field [0001] The invention relates to the field of material technology, in particular to a material for a tympanic membrane repair bracket, a preparation method and a preparation method of the tympanic membrane repair bracket. Background technique [0002] The tympanic membrane is located at the inner side of the external auditory canal and forms the outer wall of the middle ear. External sound waves pass through the external auditory canal to cause the tympanic membrane to vibrate. The tympanic membrane transmits sound to the middle ear through vibration, and then to the inner ear and the auditory cortex of the brain. The tympanic membrane is composed of an outer epithelial layer, a middle fibrous layer, and an inner mucous membrane. Studies have shown that the fibrous layer in the middle of the tympanic membrane is the most important component of the mechanical and acoustic properties of the tympanic membrane. [0003] The tympanic membrane is the outermost port...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/34A61L27/50A61L27/54A61L27/56A61L27/58A61F2/18
Inventor 柳占立施汇斌向书毅王杰孙永涛刘伟明郝亚军
Owner TSINGHUA UNIV
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