Judgment marker for cognitive impairment of Parkinson's disease and application thereof
A technology for Parkinson's disease and cognitive impairment, applied in the field of medical biology, can solve problems such as lack of biological markers
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[0055] Example 1: Preliminary exploration of the intestinal flora and metabolite characteristics of PD-CI patients
[0056] 1. Clinical data collection: Screen 13 patients with Parkinson's disease mild cognitive impairment (PD-MCI), 14 patients with normal cognitive function in Parkinson's disease (PD-NC) and 13 healthy controls (HC). The general clinical data of the subjects: the age, gender, body mass index (BMI), years of education, comorbid diseases, drug use, diet and Wexner score (constipation score) of the three groups of subjects were statistically analyzed, and the Montreal Cognitive Assessment scale (MoCA) and Mini-Mental State Examination (MMSE) to assess the overall cognitive function; and collect PD patients' course of disease, MDS-UPDRSⅢ score, Hoehn-Yahr classification, daily life ability scale and 39 items of Parkinson's disease The quality of life questionnaire was used to assess cognitive domains such as the Webster Intelligence Test and the Webster Memory Te...
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