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Judgment marker for cognitive impairment of Parkinson's disease and application thereof

A technology for Parkinson's disease and cognitive impairment, applied in the field of medical biology, can solve problems such as lack of biological markers

Pending Publication Date: 2022-02-25
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current diagnostic criteria for PD-MCI are mainly based on clinical neuropsychological assessment (Litvan I, et al.Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines.Mov Disord.2012; 27(3):349-356 ), lack of ideal biomarkers

Method used

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  • Judgment marker for cognitive impairment of Parkinson's disease and application thereof
  • Judgment marker for cognitive impairment of Parkinson's disease and application thereof
  • Judgment marker for cognitive impairment of Parkinson's disease and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Example 1: Preliminary exploration of the intestinal flora and metabolite characteristics of PD-CI patients

[0056] 1. Clinical data collection: Screen 13 patients with Parkinson's disease mild cognitive impairment (PD-MCI), 14 patients with normal cognitive function in Parkinson's disease (PD-NC) and 13 healthy controls (HC). The general clinical data of the subjects: the age, gender, body mass index (BMI), years of education, comorbid diseases, drug use, diet and Wexner score (constipation score) of the three groups of subjects were statistically analyzed, and the Montreal Cognitive Assessment scale (MoCA) and Mini-Mental State Examination (MMSE) to assess the overall cognitive function; and collect PD patients' course of disease, MDS-UPDRSⅢ score, Hoehn-Yahr classification, daily life ability scale and 39 items of Parkinson's disease The quality of life questionnaire was used to assess cognitive domains such as the Webster Intelligence Test and the Webster Memory Te...

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Abstract

The invention discloses a judgment marker for cognitive impairment of Parkinson's disease and application thereof The inventor of the invention finds that the relative abundance of the intestinal bacteria in the excrement of a PD patient is significantly related to PD-MCI, and the concentrations of isobutyric acid and isovaleric acid are related to the overall cognitive level. The composition characteristics of intestinal flora and metabolites of a PD-CI patient are researched from the metagenome level and the metabolome level, and the pathological mechanism of the PD-CI can be more comprehensively understood; and early intervention is also facilitated to slow down or treat the development of PD-CI.

Description

technical field [0001] The invention relates to the field of medical biotechnology, in particular to a marker for determining cognitive impairment of Parkinson's disease and its application. Background technique [0002] Parkinson's Disease (PD) is a common clinical neurodegenerative disease. In addition to typical motor symptoms such as resting tremor, bradykinesia, and muscle rigidity, many non-motor symptoms, including Parkinson's Disease with Cognitive Impairment (PD-CI), can also seriously affect the quality of life of patients, even Beyond motor symptoms become the main factor of disability in patients with advanced PD (Chaudhuri KR, et al; National Institute for Clinical Excellence. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol. 2006; 5(3): 235- 245.). [0003] According to the severity of the disease, PD-CI is divided into Parkinson's Disease with Mild Cognitive Impairment (PD-MCI) and Parkinson's Disease with Dementia (PDD). P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/689C12Q1/6869C12Q1/04C12N15/11G01N30/02G01N30/72
CPCC12Q1/6883C12Q1/689C12Q1/6869G01N30/02G01N30/72C12Q2531/113C12Q2535/122C12Q2537/165
Inventor 聂坤高玉元王丽娟李彦颐任腾竹张嘉辉张玉虎冯淑君
Owner GUANGDONG GENERAL HOSPITAL
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