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Biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof

A technology of lateral sclerosis and biomarkers, applied in the field of biomedicine, can solve the problems of inability to make early clinical diagnosis of sporadic ALS and PD diseases, such as effective auxiliary diagnosis

Pending Publication Date: 2021-07-23
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide a biomarker and its application for the early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease, so as to solve the problem that the biomarkers in the prior art cannot be used for sporadic ALS and Parkinson's disease. Early clinical diagnosis of PD disease plays a technical role in effective auxiliary diagnosis

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  • Biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof
  • Biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof
  • Biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof

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Embodiment

[0047] This example provides the screening process of the lncRNAs biomarkers of the present invention to find lncRNAs related to neurodegenerative diseases that are specifically differentially expressed in peripheral blood leukocytes.

[0048] A) Screening by microarray chips.

[0049] Using a chip containing 92,727 human coding and non-coding RNAs probes, we first screened dysregulated lncRNAs in 5 SALS patients and 5 healthy control samples. Using the Heatmapper software, select the top 30 lncRNAs with the greatest differences from the healthy control group, and present their expression differences in the form of a heat map, as shown in figure 1 shown. figure 1 A heat map of 30 lncRNAs with differential expression after microarray screening for SALS and healthy controls is shown in , and hierarchical clustering of samples was analyzed using average linkage clustering and Pearson distance measurement. Several different lncRNA databases, including LNCipedia, NONCODE, and Ann...

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Abstract

The invention provides a biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof, relates to the technical field of biomedicine, and solves the technical problem that in the prior art, a biomarker cannot play an effective auxiliary diagnosis role in early clinical diagnosis of sporadic ALS and PD diseases. The biomarker is lncRNAs, and a transcript of the lncRNAs includes one or more of lnc-CNTN4-2: 1, lnc-NR3C2-8: 1, lnc-ABCA12-3: 1, lnc-DYRK2-7: 1 and lnc-POTEM-4: 7. By detecting the expression level of one or more of lnc-CNTN4-2: 1, lnc-NR3C2-8: 1, lnc-ABCA12-3: 1, lnc-DYRK2-7: 1 and lnc-POTEM-4: 7, the detected results can be used as an effective method for early diagnosis of whether a patient has a high risk of suffering from sporadic amyotrophic lateral sclerosis and Parkinson's disease or not, and provides possibility for combined diagnosis of a plurality of biomarkers in the future.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a biomarker for the early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and its application. Background technique [0002] Neurodegenerative diseases are a major public health problem because neurodegenerative diseases affect nearly all age groups. Among them, amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting upper and lower motor neurons, which is characterized by selective and progressive degeneration of motor neurons and spinal and bulbar motor neurons, And involves brain dysfunction linked to one or more of the following mechanisms: oxidative stress, inflammation, and cell death. A cross-check of existing studies shows that more than 223,000 people worldwide are currently affected by ALS, and this figure will increase by 69% by 2040 due to the aging population. After the onset of symptoms, ALS patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/178C12Q2600/166C12Q2600/158
Inventor 商慧芳余玉娇李春雨庞德江欧汝威顾孝静
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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