Application of insulin-like growth factor binding protein 2 in preparation of medicine for resisting mental disorder caused by early life stress

A technology of growth factors and binding proteins, applied in the field of medicine

Active Publication Date: 2021-06-18
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant research to prove that IGFBP2 can treat anxiety and depression-like behaviors caused by early stress

Method used

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  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for resisting mental disorder caused by early life stress
  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for resisting mental disorder caused by early life stress
  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for resisting mental disorder caused by early life stress

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Establish an early stress model

[0017] SD rats are raised in a 12-hour photo / dark rhythm environment, and water and food can be freely obtained. All behavior experiments were carried out in the illumination of animals. Yin: SD pregnant in 1-3 days before production, SD-3 days single cage, the day (PND0) records the number, gender and weight of the production, and replaces the cage during the day of the production, and does not replace during breastfeeding. It is 21 days in lactation, and PND 21 separates the mouse and the mouse, and the mouse is male and female, 3-5 / cage.

[0018] The selected early stress is separated from PND 4-21, and the mouse is separated from the mouse for 4 hours, each of the signs is separated from each other, and the mouse is in different rooms. During the separation, the ambient temperature of the mouse was guaranteed at 27-33 ° C, the survival rate of the mouse was not affected, and the mouse movement of the mole was not affected. During th...

Embodiment 2

[0021] Adolescent intervention

[0022] Animals were divided into three groups, which were control group (normal feeding group), maternal and child separation group, IGFBP2 adolescent intervention group. The number of animals in three groups is greater than 10, respectively. Such as figure 1 As shown, IGFBP2 adolescent intervention time is PND 28 (note, PND is the number of days after birth), and the intervention is a tail intravenous injection, and the intervention dose is 1 μg / kg, the number of interventions is 1 time. After the intervention, the animals were returned to the breeding cage, and behavioral detection was performed at 9 weeks of age. figure 1 The RS is binding stress.

[0023] Behavioral testing is used to verify the intervention effects of mental trauma caused by IGFBP2 on early stress. All behavior experiments were performed in rats. Before behavioral experiments, rats were adapted to behavior in behavioral rooms for 2 hours. During the experiment, once a mouse ...

Embodiment 3

[0035] Adult intervention

[0036] Animals were divided into three groups, which were control groups (normal feeding groups), maternal and child separation group, IGFBP2 adult intervention group. The number of animals in three groups is greater than 10, respectively. Such as figure 1 As shown, IGFBP2 adult intervention time is PND 63, the intervention is tail intravenous injection, and the intervention dose is 1 μg / kg, and the number of interventions is once. After the intervention, the animals were returned to the breeding cage, all over the day, that is, PND64 for behavior detection.

[0037] Behavioral testing is used to verify the intervention effects of mental trauma caused by IGFBP2 on early stress. All behavior experiments were performed in rats. Before behavioral experiments, rats were adapted to behavior in behavioral rooms for 2 hours. During the experiment, once a mouse experiment was completed, a 70% alcohol was wiped, avoiding the impact of odor and the mice. Before...

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Abstract

The invention relates to application of insulin-like growth factor binding protein 2 in preparation of a medicine for resisting mental disorder caused by early life stress. IGFBP2 puberty intervention and adult intervention can significantly improve anxiety and depression behaviors caused by early life stress.

Description

Technical field [0001] The present invention relates to the field of medical technology, and more particularly to a drug in which a insulin-like growth factor binding protein 2 is prepared from mental disorders caused by early stress. Background technique [0002] In 2019, the National Health Department, the Ministry of Science and Technology "China Health Survey" indicated 20% of mental illness accounted for 20% of my country's disease burden, ranking, and the proportion of individuals with mental disabilities was 16.57% (about 230 million). Many mental illnesses are derived from stressful experiences. In the childhood, the physical psychology is not yet mature, it is more susceptible to stress, thus abnormal mental behavior. Young periodic stress incidents, including the lack of parents, parents' neglect, physical or spiritual abuse, can significantly enhance the sensitivity of adult after adult, improve the incidence of mental illness after adulthood. Early stress is a signifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P25/22A61P25/24
CPCA61K38/1754A61P25/22A61P25/24
Inventor 王振史栋栋张瀛丹
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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