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Interpretation method, system and storage medium for gene detection results of tumor individualized immunotherapy

A technology of immunotherapy and gene detection, applied in the fields of genomics, proteomics, instruments, etc., can solve problems such as lack, difficulty in interpreting results, interpretation of microsatellite instability, etc., and achieve an easy-to-understand effect

Active Publication Date: 2021-07-20
深圳裕康医学检验实验室
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Problems solved by technology

[0003] (1) Limitations in the interpretation range of indicators related to tumor immunotherapy prognosis: most products currently only include the interpretation of tumor mutation burden (TMB), PD-L1 expression, and microsatellite instability (MSI), lacking other indicators that are closely related to the prognosis of tumor immunotherapy Relevant indicators include CD8TILs, an indicator of immune cell infiltration in tumor tissue, HLA heterozygosity loss status of tumor immune escape related indicators, and positive and negative tumor immune related gene mutations (positive and negative related gene mutations include treatment resistance and hyperprogression related indicators)
[0004] (2) The results of many prognosis-related indicators of tumor immunotherapy are not clear and intuitive: most products currently only provide written descriptions of indicators related to the prognosis of immunotherapy, but there are many prognostic indicators of tumor immunotherapy, which cannot be clearly and intuitively viewed by customers. to the overall state of each indicator, making it difficult to interpret the results

Method used

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  • Interpretation method, system and storage medium for gene detection results of tumor individualized immunotherapy
  • Interpretation method, system and storage medium for gene detection results of tumor individualized immunotherapy
  • Interpretation method, system and storage medium for gene detection results of tumor individualized immunotherapy

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Experimental program
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Embodiment

[0130] The interpretation method of the patient's tumor individualized immunotherapy gene test results specifically includes the following steps:

[0131] S101: Upload the analysis result.

[0132] Genetic testing and analysis obtained 73 somatic mutations, 2 germline gene mutations, and 565 chemotherapy-related SNP site typing results, and detected TMB results as TMB-H, MSI results as MSI-H, and TNB results as TNB-H , the HLALOH result is negative, and the above results of genetic testing will be automatically uploaded to the result database after the analysis is completed.

[0133] The samples were positive for PD-L1 (TPS 20-25%) and CD8 TILs infiltration was low (Low) detected by immunohistochemistry, and the results of immunohistochemistry were manually uploaded to the result database.

[0134] S102: Variation automated classification and judgment.

[0135] Use the gene detection results of the patient detection (combined with the patient's pathological diagnosis results...

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Abstract

A method, system, and storage medium for interpreting gene detection results of individualized tumor immunotherapy. This interpretation method can classify and grade mutations in genetic testing, interpret targeted drug information related to gene mutations, and chemotherapeutic drug information related to germline single nucleotide polymorphisms, and make personalized recommendations based on patient genetic testing results Qualified clinical trial information, etc., display the results in a visualized form. This method includes the interpretation of most known biomarkers related to the prognosis of tumor immunotherapy, and can provide patients with comprehensive guidance information including tumor immunotherapy, targeted therapy, chemotherapy, and clinical trials at one time, while visually displaying the interpretation results , more intuitive and concise, easy for patients to understand.

Description

technical field [0001] The invention relates to the field of gene detection, in particular to a method, system and storage medium for interpreting gene detection results of tumor individualized immunotherapy. Background technique [0002] With the development of genetic testing technology, the use of genetic testing to guide precision medicine in the treatment of cancer patients is becoming more and more widely used. However, the products of most genetic testing institutions are mainly limited to the detection and interpretation of targeted therapy and chemotherapy. In recent years, tumor immunotherapy has developed rapidly. Eight immune checkpoint inhibitors have been approved in China, and more than 200 phase I-III clinical trials of tumor immunotherapy are underway in China. Unlike other anti-tumor treatment options, tumor immunotherapy can bring lasting benefits to patients and is a promising treatment option. Cancer patients receiving tumor immunotherapy also need prec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/30
CPCG16B20/30
Inventor 高志博王鹏吴东方杨洁陈丽何雨鸣徐丽杨露邓乙晓
Owner 深圳裕康医学检验实验室
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