Detection substance for SNP of ONFH susceptibility related VDR, MMP2, MMP3 and MMP9 genes and application
A gene and substance technology, which is applied to the detection substances and application fields of ONFH susceptibility-related VDR, MMP2, MMP3, and MMP9 gene SNPs, can solve the problem of less data on multi-gene loci, more data on gene loci, and various disadvantages. Problems such as joint pathogenicity of minor genes
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[0087] Example 1. Application of VDR, MMP2, MMP3, and MMP9 gene polymorphism combinations in detecting molecular early warning, molecular diagnosis and therapeutic drug targets of non-traumatic femoral head necrosis.
[0088] 1. Establish ONFH case-control study system
[0089] Based on informed consent, the ONFH case-control study system included 600 cases, including 300 cases in the healthy control group and 300 cases in the ONFH patient group.
[0090] ONFH cases came from inpatient clinical patients who visited the Department of Orthopedics of the Second and Third Clinical Medical Colleges of Jilin University from June 2012 to October 2018, including 204 males and 96 females, aged 54.49±11.8 years. The clinical diagnosis and staging of ONFH were performed according to the Ficat diagnosis and staging criteria, excluding obvious hip trauma history, congenital hip joint diseases, hip joint infectious diseases and hip joint tumors.
[0091] The healthy control group included ...
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