Topical compositions and methods

A composition and topical skin technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as skin irritation or insufficient moisturizing ability, unpleasant tactile properties, instability, etc.

Pending Publication Date: 2021-01-12
MARY KAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, moisturizers are not perfect
Some of the problems associated with humectants include: unpleasant tactile properties (e.g., heavy, greasy, or sticky feel), instability, skin irritation, or insufficient moisturizing capacity

Method used

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  • Topical compositions and methods
  • Topical compositions and methods
  • Topical compositions and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] (in vitro data)

[0112] B16 Pigmentation Analysis: Melanogenesis is the process by which melanocytes produce melanin, the naturally occurring pigment that gives skin, hair and eyes their color. Inhibiting melanogenesis is beneficial in preventing skin dullness and lightening dark spots associated with aging. This bioassay employs B16-F1 melanocytes (ATCC), an immortalized mouse melanoma cell line, to analyze the effect of compounds on melanin production. The endpoints of this assay are spectrophotometric measurements of melanin production and cell viability. 10% CO at 37°C 2 , B16-F1 melanocytes were cultured in standard DMEM growth medium containing 10% fetal bovine serum (Mediatech), and then treated with the amounts of components shown in Table 2 for 6 days. After incubation, cell viability was quantified by measuring melanin secretion by absorbance at 405 nm.

[0113] Table 2 (B16 melanin production data)

[0114] Element concentration inhibition%...

Embodiment 2

[0143] (body lotion preparation)

[0144] Table 11, Table 12 and Table 13 provide skin lotion formulations of the present invention structured as oil-in-water emulsions. The formulation exhibits the ability to reduce skin pigmentation, which can even out skin tone and reduce the appearance of hyperpigmented or dark spots (eg, sun spots, age spots, freckles) skin. Further, the formulation also exhibits the ability to increase skin hydration.

[0145] Table 11

[0146] Element Concentration % (by weight) water 74.29 glycerin 4.67 Hydrogenated Polydecene 3.70 Polydimethylsiloxane 2.90 Isodecyl Neopentanoate 2.15 Nicotinamide 2.00 Butanediol 1.98 vaseline 1.75 PEG-60 Glyceryl Isostearate 1.50 Cetyl Ethylhexanoate 0.90 Ammonium Acryloyldimethyltaurate / VP Copolymer 0.60 Sorbitol 0.56 Phenoxyethanol 0.48 Caprylyl glycol 0.37 plant amino acid 0.30 Acrylates / Acrylic C 10-30 Alkyl...

Embodiment 3

[0154] (Essence preparation)

[0155] Table 14 describes the serum formulations of the present invention. The formulation exhibits the ability to reduce skin pigmentation, which can even out skin tone and reduce the appearance of hyperpigmented or dark spots (eg, sun spots, age spots, freckles) skin. Further, the formulation also exhibits the ability to increase skin hydration.

[0156] Table 14

[0157] Element Concentration % (by weight) water 75.55 Propylene Glycol 6.00 Polydimethylsiloxane 5.00 glycerin 3.7 Nicotinamide 2.00 silica 2.00 Ascorbyl Glucoside 1.05 Triethanolamine 1.01 Caprylic / Capric Triglycerides 0.97 Butanediol 0.48 Ammonium Acryloyldimethyltaurate / VP Copolymer 0.40 Acrylates / Acrylic C 10-30 Alkyl Ester Crosspolymer

[0158] *Excipients may be added to alter the rheology of the formulation or provide additional skin care benefits, or to provide additional preservatives. Suc...

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Abstract

The present invention relates generally to methods of use and compositions useful for moisturizing skin and / or lightening or whitening skin. The composition includes a combination of Angelica acutiloba root extract and a Salicornia herbacea extract.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application 62 / 647,436, filed March 23, 2018, and U.S. Provisional Patent Application 62 / 799,528, filed January 31, 2019, the disclosures of which are incorporated herein by reference in their entirety. Background technique [0003] A.Technical field [0004] The present invention generally relates to topical skin compositions that can be used to cleanse, moisturize, brighten, lighten the skin and / or to improve the condition and / or visual appearance of the skin. The compositions contain a combination of skin active ingredients to achieve these effects. The combination contains Angelica acutiloba root extract and Salicornia herbacea extract for skin, which have been found to be particularly effective in lightening the skin, reducing skin inflammation, and increasing skin hydration. [0005] B. Related technical description [0006] Aging, prolonged exposure to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61K9/00A61K36/232A61K36/21A61P17/00
CPCA61K8/987A61Q19/007A61Q19/02A61Q19/00A61K2800/5922A61K8/676A61K8/675A61K8/9789A61P17/16A61K8/4926A61K8/55A61K8/345A61K8/37A61K8/8152A61K8/891A61K8/44A61K8/602
Inventor 格雷格·诺曼大卫·甘米歇尔·海尼斯利沙·万佩尔特万里·赵芭芭拉·德基李·维克斯帕特里夏·雅各比
Owner MARY KAY INC
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