Zero-order release quaternary compound of arbutin and coumaric acid, its preparation method and application

A zero-order release, coumaric acid technology, applied in applications, pharmaceutical formulations, food science, etc., can solve the problems of large fluctuations in release rate, inability to maintain the concentration of arbutin and coumaric acid, etc., to achieve simple operation, enhanced whitening Effect

Active Publication Date: 2021-08-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the release rate of the above-mentioned traditional sustained-release preparations fluctuates greatly, and the concentration of arbutin and coumaric acid cannot be maintained at a relatively stable level

Method used

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  • Zero-order release quaternary compound of arbutin and coumaric acid, its preparation method and application
  • Zero-order release quaternary compound of arbutin and coumaric acid, its preparation method and application
  • Zero-order release quaternary compound of arbutin and coumaric acid, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A preparation method of arbutin and coumaric acid zero-order release quaternary complex, the specific steps are as follows:

[0050] (1) Dissolve 1g whey protein in 100mL ultrapure water to form a 1% (w / v) whey protein (WPC) aqueous solution; dissolve 3g high methoxyl pectin in 100mL ultrapure water to form With 3% (w / v) high methoxyl pectin (HMP) aqueous solution.

[0051] (2) Mix whey protein aqueous solution and high methoxy pectin aqueous solution at a ratio of 1:1, stir magnetically at 1000 rpm for 10 min after mixing, and adjust the pH value to 3.5 to obtain WPC-HMP complex.

[0052] (3) Store the WPC-HMP complex in a refrigerator at 4°C for 12 hours to achieve complete hydration.

[0053] (4) 20 μM arbutin and 20 μM coumaric acid were simultaneously added to 50 mL of WPC-HMP complex. The mixture was stirred at 1000 rpm for 60 min, and stood in the dark for 1 h to obtain the arbutin / coumaric acid-WPC-HMP quaternary complex.

Embodiment 2

[0055] The difference from Example 1 is that the concentration of the whey protein aqueous solution is 1% (w / v), and the concentration of the high methoxyl pectin aqueous solution is 2.5% (w / v).

Embodiment 3

[0057] The difference from Example 1 is that the concentration of the whey protein aqueous solution is 1% (w / v), and the concentration of the high methoxyl pectin aqueous solution is 3.5% (w / v).

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Abstract

The invention discloses a zero-order release quaternary complex of arbutin and coumaric acid and a preparation method thereof, comprising: (1) respectively dissolving whey protein (WPC) and high methoxyl pectin (HMP) in super In pure water, whey protein aqueous solution and high methoxy pectin aqueous solution are obtained; (2) whey protein aqueous solution and high methoxy pectin aqueous solution are mixed uniformly, and its pH value is adjusted to 3-4 to obtain WPC-HMP compound; (3) leave the WPC‑HMP compound until it is fully hydrated; (4) add arbutin and coumaric acid to the fully hydrated WPC‑HMP compound, stir and mix well, and let it stand in the dark The zero-order release quaternary complex of arbutin and coumaric acid was obtained after storage. The invention also discloses the application of the zero-order release quaternary complex of arbutin and coumaric acid as an arbutin and coumaric acid additive in the preparation of functional food or cosmetics. The zero-order release quaternary complex of arbutin and coumaric acid can realize the zero-order release of arbutin and coumaric acid.

Description

technical field [0001] The invention relates to the technical field of preparation of arbutin and coumaric acid complexes, in particular to the zero-order release quaternary complex of arbutin and coumaric acid and its preparation method and application. Background technique [0002] Both arbutin and coumaric acid are important plant phenolic substances, which have been widely used in food, cosmetics and pharmaceuticals due to their unique biological activities. Among them, arbutin is reported to have skin whitening, anti-aging and anti-cancer effects; coumaric acid has anti-oxidation, whitening, anti-inflammatory and anti-cancer activities. Studies have shown that both arbutin and coumaric acid interfere with melanin formation, so applying them together can effectively provide a synergistic effect. [0003] However, due to the hydrophilic nature of arbutin and the hydrophobic nature of coumaric acid, applying both substances simultaneously is a difficult task. [0004] In...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61K8/365A61K8/64A61K8/73A61Q19/00A23L33/00
CPCA23V2002/00A61K8/365A61K8/602A61K8/64A61K8/73A61Q19/00A23L33/00A23V2200/318A23V2250/54252A23V2250/50722
Inventor 罗自生黄皓林星宇李莉吴元锋
Owner ZHEJIANG UNIV
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