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Application of ester-containing aromatic propionamide compounds and their metabolites in the preparation of drugs for the treatment of heart failure

A technology of ester-based aromatic propionamides and compounds, applied in the field of medicine, can solve problems such as decreased left ventricular compliance, myocardial contractility can not exert the ejection effect, myocardial function decompensation, etc., to improve the ejection fraction, easy to understand , Improve the effect of LVSP

Active Publication Date: 2022-07-15
CHANGCHUN GENESCIENCE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The increase of fibrosis reduces the compliance of the left ventricle, and the myocardial contractility cannot exert its proper ejection effect, thus forming a vicious circle, resulting in decompensation of myocardial function, and finally leading to heart failure

Method used

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  • Application of ester-containing aromatic propionamide compounds and their metabolites in the preparation of drugs for the treatment of heart failure
  • Application of ester-containing aromatic propionamide compounds and their metabolites in the preparation of drugs for the treatment of heart failure
  • Application of ester-containing aromatic propionamide compounds and their metabolites in the preparation of drugs for the treatment of heart failure

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Experimental program
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Embodiment Construction

[0027] The invention discloses the application of an ester group-containing aryl propionamide compound in the preparation of a medicine for treating heart failure. The following specific experiments are used to confirm the application of the invention. The EG017 mentioned in the text is C 25 H 17 F 3 N 4 O 4 , the preparation method and structural formula of EG017 refer to the content recorded in the patent document with patent number CN201410033958.0. In all the drawings of the present invention, the columns are arranged in the order of Sham, Model, and EG017 groups from left to right.

[0028] Instruments used in the experiments of the present invention

[0029] Small animal ventilator, model: V-200046; manufacturer: Harvard Apparatus.

[0030] Vevo Small Animal Ultrasound Imaging System, Model: 1100, Manufacturer: Visualsonics.

[0031] Powerlab 8 / 35 signal acquisition system, model: 8 / 35, manufacturer: ADinstrunents.

[0032] Animal experimental treadmill, model: D...

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Abstract

The invention discloses the application of an ester-containing aromatic propionamide compound and its metabolite in preparing a medicine for treating heart failure, wherein the ester-containing aromatic propionamide compound is C 25 H 17 F 3 N 4 O 4 The outstanding effect of the present invention is that the ester-containing aromatic propionamide compound can improve the ejection fraction, short-axis shortening rate and cardiac output reduction of chronic heart failure rats, and increase the LVSP of heart failure rats. It can play a very positive role in the application of preparing medicine for treating heart failure.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of an ester group-containing aromatic propionamide compound and its metabolite in the preparation of a medicine for treating heart failure. Background technique [0002] Heart failure, referred to as heart failure, refers to the failure of the systolic and / or diastolic function of the heart to fully discharge the venous blood back to the heart, resulting in blood stasis in the venous system and insufficient blood perfusion in the arterial system, resulting in cardiac circulatory disorder syndrome. , This disorder symptoms cluster manifested as pulmonary congestion, vena cava congestion. The occurrence of heart failure is generally due to the apoptosis of cardiomyocytes after myocardial infarction, resulting in the progressive loss of effective contractile function units-cardiomyocytes, the enhancement of the compensatory function of viable cardiomyocy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4406A61P9/04
CPCA61K31/4406A61P9/04A61K31/455
Inventor 朱新法朱然
Owner CHANGCHUN GENESCIENCE PHARM CO LTD
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