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Application of total saponins of American ginseng stems and leaves in the preparation of a composition for combating bone loss caused by weightlessness

A technology of total saponins and American ginseng, applied in the field of biomedicine, can solve the problem of no bone loss and the like, and achieve the effect of reducing bone loss

Active Publication Date: 2022-05-20
63919 TROOPS PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Xinyue Capsules, which mainly contain total saponins from stems and leaves of American ginseng, have been clinically used for more than 20 years. At present, there is no research on the application of total saponins from stems and leaves of American ginseng to combat bone loss caused by weightlessness / simulated weightlessness.

Method used

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  • Application of total saponins of American ginseng stems and leaves in the preparation of a composition for combating bone loss caused by weightlessness
  • Application of total saponins of American ginseng stems and leaves in the preparation of a composition for combating bone loss caused by weightlessness
  • Application of total saponins of American ginseng stems and leaves in the preparation of a composition for combating bone loss caused by weightlessness

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Experimental program
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Embodiment 1

[0020] The main component of the total saponins of American ginseng stems and leaves used in the present invention is Xinyue Capsules (National Drug License No. Z20030073), which is used in clinical practice.

[0021] 1. Effects of total saponins from American ginseng stems and leaves on the body weight of mice with bone loss induced by simulated weightlessness.

[0022] 1.1 Animals and experimental drugs

[0023] Fifty healthy male C57BL / 6 mice were selected; they were reared in separate cages in a breeding room with natural light and artificial light in an environment with a temperature of 22°C-26°C and an air humidity of 45%-65%. Drinking water; adaptive feeding for one week. The experimental drug American ginseng stem and leaf total saponin (99.0% purity) was provided by Ji'an Yisheng Pharmaceutical Co., Ltd., Jilin Province.

[0024] 1.2 Modeling and grouping

[0025] 1.2.1 Establishment of mouse tail suspension simulated weightlessness model

[0026] Wash the surface...

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Abstract

The invention discloses the application of the total saponins of American ginseng stems and leaves in the preparation of a composition for fighting bone loss. The beneficial effect of the present invention is: the application of the total saponins of American ginseng stems and leaves provided by the present invention in the preparation of a composition for combating bone loss, and simulation experiments show that the total saponins of American ginseng stems and leaves can reduce bone loss in mice caused by simulated weightlessness , which means that the use of total saponins from American ginseng stems and leaves can effectively resist bone loss caused by special environments such as aerospace.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of total saponins from stems and leaves of American ginseng in the preparation of a composition for combating bone loss. Background technique [0002] During long-term space flight, bone loss occurs as a result of the combined effects of increased bone resorption and decreased bone formation. In microgravity, the rate of bone loss is more than 10 times the monthly loss of bone density in postmenopausal women on the ground. Bone density lost during a 6-month space flight is largely regained about 1,000 days after returning to Earth. However, the structural changes are irreversible, similar to those that occur in senile osteoporosis. In a series of adaptive changes in the human body in the microgravity environment, most of the system changes are self-limiting, and only the changes in the skeletal system show a progressive process. The detection of the bone de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P19/08A23L33/105
CPCA61K36/258A61P19/08A23L33/105A23V2002/00A23V2200/306
Inventor 李英贤史大卓梁帅杜锐凯凌树宽
Owner 63919 TROOPS PLA
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