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Method and system for identifying non-coding RNA (lnRNA) regulated disease risk target pathways

A technology of disease risk and identification method, which is applied in the field of identification method and system of non-coding RNA regulation disease risk target pathway, which can solve the problem that the function of lncRNA is not very clear

Active Publication Date: 2020-11-06
李霞 +2
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Problems solved by technology

However, current research on the mechanism and function of lncRNAs in complex diseases is only the tip of the iceberg, and the functions of most lncRNAs are still not very clear

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  • Method and system for identifying non-coding RNA (lnRNA) regulated disease risk target pathways
  • Method and system for identifying non-coding RNA (lnRNA) regulated disease risk target pathways

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Embodiment Construction

[0059] The purpose of the present invention is to provide a method and system for identifying non-coding RNA-regulated disease risk target pathways, so as to realize systematic identification of risk target pathways affected by lncRNA regulation in complex diseases, and reveal the regulatory role and function of lncRNA in diseases. The perspective of coding RNA regulation provides a new reference for the study of the pathogenic mechanism of complex diseases.

[0060] In order to make the above objects, features and advantages of the present invention more comprehensible, the invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0061] The present invention considers that the abnormal expression of lncRNA will affect the expression of tumor-related genes and proteins, leading to the dysfunction of important disease-related biological processes and pathway functions, thereby leading to the occurrence and deve...

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Abstract

The invention discloses a method and a system for identifying lnRNA regulated disease risk target pathways. According to the method, risk pathway regions regulated and controlled by lncRNA in different disease types can be finely identified based on a lncRNA expression profile, an lncRNA-protein coding gene association interaction network and the expression disorder degrees of genes, which are located in pathways, in diseases, and taking multiple factors such as the association of the genes in the pathways and expression disorder lncRNA, the expression disorder degrees of the genes and the topological structures of the pathways into consideration; and the risk target pathways influenced by lncRNA regulation and control in complex diseases can be systematically identified, so the regulationand control effect and the functions of lncRNA in diseases can be revealed, and a novel reference is provided for the research of the pathogenesis of complex diseases from the perspective of non-coding RNA regulation and control.

Description

technical field [0001] The invention relates to the technical field of human genome, in particular to a method and system for identifying a non-coding RNA-regulated disease risk target pathway. Background technique [0002] The proposal of the Human Genome Project and the development of high-throughput sequencing technology have prompted researchers to discover a new class of non-coding RNA—long non-coding RNA (lncRNA), which is a type of non-coding RNA (lncRNA) that exists widely in animals and plants. An RNA transcript molecule of 200 bases (nucleotide, nt) that usually does not encode a protein. Based on next-generation sequencing technology, researchers have obtained a large number of lncRNA data at different omics levels, such as expression and genetic variation data, and found that lncRNA can regulate many important biological functions at the post-transcriptional level. Subsequently, more and more studies have proved that lncRNAs participate in the regulation of a wi...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00G16B20/30G16B50/00
CPCG16B20/00G16B20/30G16B50/00Y02A90/10
Inventor 张云鹏许艳军李峰李霞
Owner 李霞
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