Compositions and methods of treatment for neurological disorders comprising motor neuron diseases

A family-based, alkyl-based technology that can be used in neurological diseases, drug combinations, pharmaceutical formulations, etc., to solve problems such as brain loss of initiation and control of voluntary movements

Pending Publication Date: 2020-09-11
格利亚制药股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Eventually, the brain loses its ability to initiate and control voluntary movements

Method used

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  • Compositions and methods of treatment for neurological disorders comprising motor neuron diseases
  • Compositions and methods of treatment for neurological disorders comprising motor neuron diseases
  • Compositions and methods of treatment for neurological disorders comprising motor neuron diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0342] Example 1 - Molecules of the invention are used in the testing of ALS

[0343] Materials and methods

[0344] 1. Mouse animal experiments

[0345] All experiments were performed in accordance with the Swiss Federal Guidelines for Animal Experimentation and were approved by the Cantonal Veterinary Office for Animal Experimentation in Switzerland.

[0346] 2. cell culture

[0347] Primary cultures of cortical astrocytes were obtained from 1-2 day old OF1 mouse pups (Charles River Laboratories). Briefly, cortices were isolated and minced into small pieces under a dissecting microscope. Cells were incubated for 30 min at 37° C. in a solution containing 20 U / ml of papain (Worthington Biochemical), L-cysteine ​​1 mM (Sigma) and 10 kU / ml DNase I (Worthington Biochemical) for enzymatic dissociation. Papain activity was stopped by adding fetal calf serum (FCS) to the solution, and then mechanically dissociated to obtain a single cell suspension in DMEM containing 10%...

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PUM

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Abstract

This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.

Description

[0001] field of invention [0002] In at least some aspects, the invention relates to compositions and methods of treating neurological disorders, and in particular to compositions comprising molecules of the invention as described herein and methods of treatment using such compositions. [0003] Background of the invention [0004] Amyotrophic lateral sclerosis (ALS) is a rare neurological disease that belongs to the broader group of neurological diseases known as motor neuron diseases (MND). ALS primarily affects the nerve cells (neurons) responsible for controlling voluntary muscle movement. The disease is progressive. Currently, there is no cure for ALS and no effective treatment to halt or reverse the progression of the disease. Two existing drugs for ALS, Riluzole and Edaravone, were shown to extend patients' lives by only a few months. [0005] ALS belongs to a broader group of disorders known as motor neuron diseases, which are caused by the progressive deterioration...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D231/56C07D401/12C07D409/04C07D413/12C07D471/04C07D261/20C07D487/04C07D491/048C07D277/04C07D213/42A61P25/28
CPCC07D231/56C07D401/12C07D409/04C07D413/12C07D471/04C07D261/20C07D487/04C07D491/048C07D277/04C07D213/42A61P25/28A61K31/4152A61K31/428C07D239/70C07D403/04C07D403/12C07D403/14C07D405/14C07D409/14
Inventor 西尔万·伦加彻查尔斯·芬斯特沃德皮埃尔·马吉斯特提
Owner 格利亚制药股份公司
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