Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri

A technology of Providencia rettgeri and Providencia bacteria, applied in the direction of antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effect of wide application value

Active Publication Date: 2020-06-05
SHAANXI UNIV OF SCI & TECH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology can help prevent Multi Drug Resistance (MDR) caused by certain compounds from causing harm or even death for people who are already taking multiple drugs simultanously.

Problems solved by technology

The technical problem addressed in this patents relates to finding novel ways to prevent and treat microorganisms like those found naturally occurring within humans through use of probes called Microbactors® derived from Palexporidae Root Body Fungi. These agents include several types including butterburazoxane, nigerospondezvousness virus-, cytotaxel-, shuttlefish lyssinochlorophyll-17B) and certain metabolites produced by these generators.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri
  • Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri
  • Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0022] Pulsatilla saponin A3, the English name is Anemoside A3 Pulchinenoside A3, the molecular formula is C 41 h 66 o 12 , relative molecular mass is 750.95554, density: 1.31, solubility: soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. Appearance: white crystalline powder. The source of extraction is Pulsatilla pulsatillae, a plant of Ranunculaceae. The CAS number is 129724-84-1, the CB number is CB42491699, and the molecular structure is as follows:

[0023]

[0024] 1. Drug susceptibility test of Providencia rettgeri

[0025] The present invention takes 5 strains of Providencia rettgeri from Ningbo Women and Children's Hospital as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of pulsatilla saponin A3 in inhibiting the growth of multi-drug-resistant Providencia rettgeri. According to the invention, the pulsatilla saponin A3 has good in-vitro killing effect on human-derived Providencia rettgeriis with resistance to ampicillin, ampicillin/sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin tazobactam,ciprofloxacin, levofloxacin, amikacin, compound phenoxymine, cefepime, ertapenem, imipenem, aztreonam and gentamicin, can inhibit in-vitro growth of the multi-drug-resistant Providencia rettgeri, andhas a minimum inhibitory concentration of 125 [mu]g/mL and a minimum bactericidal concentration of 250 [mu]g/mL. The pulsatilla saponin A3 provided by the ivnention has an antibacterial effect on themulti-drug-resistant Providencia rettgeri, can relieve or solve the problem that the drug resistance of the multi-drug-resistant Providencia rettgeri is increased, and provides a theoretical basis forclinical antibacterial treatment and novel drug research and development.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Owner SHAANXI UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com