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Application of fad in the preparation of drugs for inhibiting or treating diseases of the cardiovascular system

A cardiovascular and disease technology, which is applied in the application field of FAD in the preparation of drugs for inhibiting or treating cardiovascular system diseases, can solve the problem of blood perfusion not returning to normal, no early intervention or long-term effective treatment, heart, brain and kidney injury. Not significantly improved, etc.

Active Publication Date: 2021-09-10
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the clinical treatment of hypertension, although the blood pressure drops to the normal range during the treatment, the damage of target organs such as the heart, brain, kidney, etc. caused by hypertension has not been significantly improved, which is related to the fact that the blood perfusion has not returned to normal
[0003] Heart failure is the terminal stage of chronic cardiovascular disease, and to date, few therapies allow for early intervention or long-term effective treatment

Method used

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  • Application of fad in the preparation of drugs for inhibiting or treating diseases of the cardiovascular system
  • Application of fad in the preparation of drugs for inhibiting or treating diseases of the cardiovascular system
  • Application of fad in the preparation of drugs for inhibiting or treating diseases of the cardiovascular system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Example 1 Change artery systolic pressure of rats embodiment

[0075] 1, the present embodiment different dosing cycle test period tail artery systolic pressure changes in the SBP of rats.

[0076] 2, as a result figure 1 Shown, SHR + NS group was sustained by hypertension, SBP and SHR + FAD decreased administration group after 2 weeks 4 weeks up to 10 weeks decreased SBP same dosing period, but decreased compared to degree of drug two weeks has slowed the process of cardiac hypertrophy and fibrosis in SHR rats were related.

[0077] The results show, FAD reduce persistent hypertension SHR rats.

Embodiment 2

[0078] Index changes echocardiographic ultrasound rats in each group in Example 2

[0079] 1, the changes of each index according to the present embodiment to test groups of rats echocardiography.

[0080] 2, as a result figure 2 Shown in Panel A shows real-time echocardiographic image, B shows the change of each index. Wistar + NS group, Wistar + FAD left ventricular systolic and diastolic function properly front wall of the rear wall, no significant difference between the groups. Compared with Wistar group, the SHR group EF, FS, LVIDd, LVIDs significantly reduced, LVAWd, LVAWs, LVPWd, LVPWs significantly increased, indicating that the 22-week-old spontaneously hypertensive rats cardiac systolic and diastolic dysfunction, cardiac pump function disorders, decreased heart function. Compared with the group of SHR, SHR + FAD group EF, FS, LVIDd, LVIDs significantly increased. LVAWd, LVAWs, LVPWd, LVPWs significantly reduced.

[0081] The results showed that after intravenous injectio...

Embodiment 3

[0082] Changes in cardiac hypertrophy indicators 3 rats EXAMPLE

[0083] 1, the present embodiment changes the test indicators of cardiac hypertrophy rats.

[0084] 2, as a result image 3 , As compared with normal saline group, the saline group the ventricular wall SHR rats was significantly thicker, significantly reduced the ventricular cavity, in myocyte surface area increased significantly, showing a typical concentric hypertrophy. After tail vein injection FAD (0.83mg / kg / d) treating ventricular wall SHR treated rats was significantly thinner, significantly increased ventricular cavity, the surface area is significantly reduced myocardial cells, cardiac hypertrophy was reduced. Compared with normal saline group, left ventricular mass index saline SHR rats was significantly increased; and left ventricular mass index SHR treated rats decreased significantly. Compared with normal saline group, pathological cardiac hypertrophy markers ANF, mRNA expression of BNP was significant...

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Abstract

The invention relates to the technical field of biomedicine, and discloses the application of FAD in the preparation of drugs for inhibiting or treating diseases of the cardiovascular system. Application of FAD in preparing drugs for inhibiting or treating diseases of the cardiovascular system by activating SCAD targets. The present invention discovers and proves for the first time that FAD has the effect of improving hypertension, vascular remodeling, pathological myocardial hypertrophy, myocardial fibrosis and heart failure.

Description

Technical field [0001] The present invention relates to the field of biotechnology medicine, in particular to the use of FAD system for preparing medicament inhibiting cardiovascular disease or treatment. Background technique [0002] Hypertension is the most common cardiovascular disease, can lead to problems of stroke, coronary heart disease, heart failure and kidney disease. High blood pressure, blood flow or blood flow rate increases, the shear stress on the vessel wall, increased vascular wall tension, can lead to vessel wall thickening, decreased vascular compliance. Vascular remodeling in hypertension affects nearly all tissues and organs. The clinical treatment of hypertension, although blood pressure to the normal range during the treatment period, however, complicated by high blood pressure damage the heart, brain and kidney and other target organs has not been significantly improved, which with its perfusion is not restored to normal about. [0003] Heart failure is th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7084A61P9/00A61P9/12A61P9/04
CPCA61K31/7084A61P9/00A61P9/04A61P9/12
Inventor 周四桂马智超钟小艺苏永少秦学
Owner GUANGDONG PHARMA UNIV
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