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Medium chain fatty acids for use in the prevention or treatment of cardiac enlargement and/or valvular heart disease

A technology for medium-chain fatty acids and heart enlargement, applied in the field of medium-chain fatty acids or compositions containing medium-chain fatty acids, capable of solving problems such as increased risk

Inactive Publication Date: 2020-01-10
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs can have side effects, and the risk of such side effects can increase with increasing doses, which may be necessary when the condition or symptoms worsen or when the body develops tolerance to the drug's effects

Method used

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  • Medium chain fatty acids for use in the prevention or treatment of cardiac enlargement and/or valvular heart disease
  • Medium chain fatty acids for use in the prevention or treatment of cardiac enlargement and/or valvular heart disease
  • Medium chain fatty acids for use in the prevention or treatment of cardiac enlargement and/or valvular heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] By way of example and not limitation, the following non-limiting studies exemplify compositions and methods using MCTs for cardioprotection and treatment of mitral valve degenerative disease (DMVD) in dogs in one or more embodiments provided herein .

[0137] Example 1 - Heart Health Blend (Cardioprotective Blend (CPB)) Study in Canines with DMVD Nineteen healthy dogs and 21 dogs with heart murmurs were selected for a 6-month study. All dogs were examined using echocardiography by board-certified veterinary cardiologists and were identified as either healthy or with early DMVD. Dogs in each group were randomly divided into two dietary treatment groups based on age, sex, breed, weight, and murmur grade. The control diet, manufactured by Nestle Purina PetCare Company, provided complete and balanced nutrition to meet or exceed the requirements set forth by the Association of American Feed Control Officials (AAFCO). The test diet contained all the components of the contro...

Embodiment 2

[0173] Nutritional supplements with the following ingredients are provided:

[0174] Table 1: Composition of Example 1

[0175] Element Amount in Daily Dose MCTs with 53% C8 and 47% C10 fatty acids) 15g DHA 250mg EPA 250mg Lysine 2g Methionine 250mg cysteine 250mg magnesium sulfate 500mg Vitamin E 30μg taurine 250mg

[0176] Add the mixture to the blueberry muffin mixture and bake at 200°C for 15 minutes. Muffins may be administered in combination with another MCT-containing product.

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PUM

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Abstract

Medium chain fatty acids or a composition comprising medium chain fatty acids for use in the prevention or treatment of cardiac enlargement, valvular heart disease and / or a condition associated with either of the foregoing in a human.

Description

[0001] The present invention relates to medium chain fatty acids or compositions comprising medium chain fatty acids for use in the prevention or treatment of cardiac enlargement and / or valvular heart disease and / or conditions associated with any of the foregoing in an individual. Background technique [0002] The heart's job is to pump blood throughout the body to ensure an optimal supply of oxygen and nutrients to all tissues. This supply of oxygen and nutrients can be compromised if the heart is not pumping as efficiently as it should. If heart failure develops, the heart's efficiency at delivering oxygen and nutrients to tissues is affected, and other organ failure and sudden death may ensue. [0003] Abnormal heart enlargement and valvular heart disease are conditions that can negatively affect the heart's ability to pump blood throughout the body. [0004] Treatment of abnormal heart enlargement and / or valvular heart disease typically focuses on treating one or more und...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/23A61K33/06A61P9/04A61K31/198A61P9/06A61P9/00A61P9/12A61K31/19A61K31/20A61K31/225A61K45/06A61K31/355A61K31/185
CPCA61K45/06A61K31/185A61K31/19A61K31/198A61K31/20A61K31/225A61K31/23A61K31/355A61K33/06A61P9/04A61P9/06A61P9/00A61P9/12A61K2300/00A23L33/12A23L33/175A23L33/16A23L33/15A61P9/10A23V2002/00A61K31/145A61K31/202
Inventor Q·李M·博蒙特
Owner SOC DES PROD NESTLE SA
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