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Composition containing pyridyl pyrimidinamine compounds and application thereof

A technology of pyridyl pyrimidine amine and second pyridyl pyrimidine amine, which is applied in the field of compositions containing pyridyl pyrimidine amine compounds, and can solve problems that need to be further improved

Inactive Publication Date: 2019-12-13
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as horn wind, six ear bells, rattan notoginseng, Guanzhong, golden thread grass, unipedal wind,...

Method used

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  • Composition containing pyridyl pyrimidinamine compounds and application thereof
  • Composition containing pyridyl pyrimidinamine compounds and application thereof
  • Composition containing pyridyl pyrimidinamine compounds and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0044] The preparation of preparation example 1 plant extract

[0045] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, 50g of plant dry powder was weighed, and methanol was added for ultrasonic extraction, 60min each time, and the extraction was repeated 3 times. Concentrate after filtration and store in a refrigerator at 4°C until use.

[0046] The plant material is selected from the group consisting of Bone Fracture (PGF), White Diamond (BZ), Mountain Star Anise (SBJ) and Laijiao Feng (LJF).

Embodiment 1

[0119] Embodiment 1 Oral solid preparation containing pyridyl pyrimidine amine compound and its preparation method

[0120] Prescription (1500 unit dose)

[0121]

[0122]

[0123] Preparation

[0124] Take the mixture X-Y-PE and auxiliary materials in the prescribed amount, and pass through a 100-mesh sieve. Take the mixture X-Y-PE, lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; take the prescribed amount of hypromellose, and prepare a solution with a concentration of 10% based on hypromellose, Use lactic acid to adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules;

[0125] Take the mixture X-Y-PE and auxiliary materials in the prescribed amount, and pass through a 10...

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Abstract

The invention provides a composition containing a mixture of a first pyridyl pyrimidinamine compound and a second pyridyl pyrimidinamine compound, wherein structures of the first pyridyl pyrimidinamine compound and the second pyridyl pyrimidinamine compound are shown as a formula II but are different from each other. The specific definition of each substituent group is as shown in the specification. The mixture disclosed by the invention can generate a synergistic antibacterial effect with extracts of plants such as root and stem leaf of Jasminum lanceolarium Roxb., root and rattan of Kadsurasp., fructus anisi stellati, Sabia fasciculata Lec., etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing pyridyl pyrimidine amine compounds. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN08939081A discloses an antibacterial composition containing metformin and a pyridylpyrimidine amine compound represented by formula I, and discloses the antibacterial activity of the compound when administered alone. [0004] [0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K36/63A61K36/79A61K36/57A61K36/746A61K36/9062A61P31/02
CPCA61K31/506A61K36/57A61K36/63A61K36/746A61K36/79A61K36/9062A61P31/02A61K2300/00
Inventor 向飞卢剑飞
Owner 黄泳华
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