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Use of miR-327 inhibitors and/or FGF10 promoters in drugs for the prevention and/or treatment of lipodystrophy

A 1.mir-327, inhibitor technology, applied in the field of medicine, can solve problems such as health hazards and obesity

Active Publication Date: 2021-07-20
义慧科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the commercially available drugs for the treatment of obesity, most of them are based on methods such as emetic induction and appetite suppression to reduce the intake of energy in the body so as to achieve the goal of weight loss, but this will cause certain harm to health and cannot radically change obesity

Method used

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  • Use of miR-327 inhibitors and/or FGF10 promoters in drugs for the prevention and/or treatment of lipodystrophy
  • Use of miR-327 inhibitors and/or FGF10 promoters in drugs for the prevention and/or treatment of lipodystrophy
  • Use of miR-327 inhibitors and/or FGF10 promoters in drugs for the prevention and/or treatment of lipodystrophy

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Experimental program
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Embodiment 1

[0054] Embodiment 1 administers drugs to mice, and explores the influence of drugs on the weight and shape of adipose tissue

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Abstract

The present invention provides new applications of miR-327 inhibitors and / or FGF10 promoters, especially the applications in the preparation of drugs for preventing and / or treating diabetes. miR-327 inhibitors and FGF10 promoters can both promote the increase of FGF10 in the stromal cell components of adipose tissue, promote the differentiation of stromal cell component adipocyte precursors into brown adipocytes, increase energy consumption, and promote fat metabolism, thereby preventing And / or the effect of treating lipodystrophy. The present invention also provides a drug for preventing and / or treating lipodystrophy, including miR‑327 inhibitor and a pharmaceutically acceptable carrier thereof.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of miR-327 inhibitors and / or FGF10 promoters in drugs for preventing and / or treating lipodystrophy. Background technique [0002] Fat metabolism is the process of digestion and absorption, synthesis and decomposition of fat in the body with the help of various related enzymes, and it is processed into the substances needed by the body to ensure the normal operation of physiological functions, which is of great significance to life activities. Diseases caused by abnormal fat metabolism are common diseases in modern society. Among them, obesity is a common fat metabolism disease, characterized by an increase in the volume and number of fat cells in the body leading to an abnormally high percentage of body fat in body weight and excessive fat deposition in some localities. According to statistics, 15%-20% of patients who die from diseases are accompanied by obesit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K38/18A61K31/7105A61P3/00
Inventor 杨云龙曹义海
Owner 义慧科技(深圳)有限公司
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