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A tripeptide with ACE inhibitory activity and DPP-IV inhibitory activity

A technology of DPP-IV and inhibitory activity, applied in the direction of peptides, etc., can solve problems such as health hazards

Inactive Publication Date: 2020-10-20
BOHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, synthetic inhibitors have potential health hazards

Method used

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  • A tripeptide with ACE inhibitory activity and DPP-IV inhibitory activity
  • A tripeptide with ACE inhibitory activity and DPP-IV inhibitory activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. Screening of tripeptides with ACE inhibitory activity and DPP-IV inhibitory activity

[0034] In the present invention, the pepsin and trypsin of ExPASy PeptideCutter (http: / / web.expasy.org / peptide_cutter / ) are used to carry out virtual digestion of egg protein, and the peptide sequence generated after the digestion is combined with BIOPEP (http: / / www. uwm.edu.pl / biochemia / index.php / en / biopep) database known ACE inhibitory and DPP-IV inhibitory peptides were compared, and unreported peptides FGR, GCR, CDR, FK, NTF, NAF, FYQ, QGF, QGL, ADF. Water solubility, biological activity and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties of FGR were predicted by the online tool peptide property calculator, PeptideRanker and the ADMET program in DiscoveryStudio (DS) 2017. The screened peptides FGR, CDR, FK and ADF have good solubility, activity score higher than 0.5, and non-toxic. The crystal structure of human ACE complexed with linazepr...

Embodiment 2

[0035] Example 2. Identification of ACE inhibitory activity and DPP-IV inhibitory activity of FGR in vitro

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Abstract

The invention discloses a tripeptide with ACE inhibitory activity and DPP-IV inhibitory activity, and its amino acid sequence is Phe-Gly-Arg (FGR). The tripeptides with ACE inhibitory activity and DPP‑IV inhibitory activity provided by the present invention have sustained and stable inhibitory effects on ACE and DPP‑IV respectively, and are safe, non-toxic, easy to absorb, etc., and can be used as functional ingredients in In food, health products and antihypertensive drugs, it has broad application prospects and very important significance.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a tripeptide with ACE inhibitory activity and DPP-IV inhibitory activity. Background technique [0002] At present, many hypertensive patients, especially the obese type, are often accompanied by diabetes, and more diabetic patients are accompanied by hypertension. The blood vessels of diabetic patients are sensitive to angiotensin, which has a boosting effect; diabetes can easily cause kidney damage, and after kidney damage It can increase blood pressure, so the two are called homologous diseases. The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating blood pressure by controlling arteriolar vasoconstriction and intravascular fluid volume. RAAS is mainly regulated by angiotensin converting enzyme (ACE). Therefore, ACE is a key target for the treatment of hypertension, and ACE inhibitory peptides can reduce hypertension after oral administ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/087
Inventor 赵文竹张丹于志鹏赵德荀
Owner BOHAI UNIV
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