Blood glucose adjusting mechanism based on COX (cyclooxygenase)
A regulation mechanism, COX-2 technology, applied in the field of biomedicine, can solve problems such as side effects, weight gain, edema side effects, etc.
Inactive Publication Date: 2019-03-05
任洁
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Problems solved by technology
However, the existing methods for the treatment of diabetes have certain defects
Examples include insulin injections and sulfonylureas, which may cause hypoglycemia and weight gain; metformin, alpha-glucosidase inhibitor
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The invention belongs to the field of biological medicines, relates to COX (cyclooxygenase) involved multi-target blood glucose adjusting mechanism, and provides a novel mechanism for preventing or treating diabetes, metabolic syndromes and related diseases of the diabetes and the metabolic syndromes. Medicines or medicine compositions can adjust blood glucose by multi-target protection pancreas islet beta cells acting onto COX and/or GPR and/or PPAR and adjustment of insulin secretion or improvement of insulin sensibility. Therefore, a new approach and means can be provided for preventing ortreating diabetes, metabolic syndromes and related diseases of the diabetes and the metabolic syndromes.
Description
technical field [0001] The invention belongs to the field of biomedicine and relates to a multi-target blood sugar regulation mechanism in which COX participates. The present invention provides a mechanism for preventing or treating diabetes, metabolic syndrome, and related diseases. The drug or pharmaceutical composition can protect pancreatic islet β cells, regulate insulin secretion or increase insulin secretion by acting on COX and / or GPR and / or PPAR multi-target Insulin sensitivity to regulate blood sugar. Therefore, the present invention will provide a new approach and means for preventing or treating diabetes, metabolic syndrome, and related diseases. Background technique [0002] Diabetes is a disease of energy metabolism and is mainly divided into type 1 diabetes (insulin-dependent diabetes) and type 2 diabetes (non-insulin-dependent diabetes). At present, there are about 366 million diabetic patients in the world, accounting for 6.4% of the world's population, ...
Claims
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Login to view more IPC IPC(8): A61K45/06A61K31/343A61K31/192A61K31/4439A61K31/155A61P3/10A61P3/00A61P5/50
CPCA61K31/155A61K31/192A61K31/343A61K31/4439A61K45/06A61K2300/00
Inventor 任洁王学堃张瑜
Owner 任洁
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