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A method for inhibiting the activity of acetylcholinesterase

A technology for the activity of acetylcholinesterase, which is applied in the field of inhibiting acetylcholinesterase activity, can solve problems such as incomplete symptom relief, and achieve good results

Active Publication Date: 2021-12-03
HUIZHOU UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Not only that, but these approved drugs, including cholinesterase inhibitors, N-methyl-D-aspartate (NMDA) receptor antagonists, or combinations thereof often provide temporary and incomplete symptom relief, with serious side effects

Method used

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  • A method for inhibiting the activity of acetylcholinesterase
  • A method for inhibiting the activity of acetylcholinesterase
  • A method for inhibiting the activity of acetylcholinesterase

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Embodiment Construction

[0027] The present invention will be described in further detail below in conjunction with specific embodiments.

[0028] The preparation method of the extract preparation is as follows:

[0029] Wash the fresh products of the yellow skin, peel and remove the core; dry the separated branches, leaves, pulp, core, and peel of the yellow skin in an electric blast drying oven at 45 °C.

[0030] Grind with a traditional Chinese medicine grinder, sieve, take 10g of powder, dissolve in 100mL of 95% ethanol, extract with 300W ultrasonic wave for 30min, filter with suction, extract continuously for 3 times, and combine the extracts.

[0031] Distill the extract under reduced pressure (temperature not higher than 50°C; speed: 60rpm) to obtain ethanol extract extract, add 100mL distilled water to soak and dissolve, and extract 3 times with petroleum ether (100mLx3) and ethyl acetate (100mLx3) The second time, the extracts were combined, the water phase was retained, and the vacuum disti...

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Abstract

The invention relates to the field of biotechnology, and discloses a method for inhibiting the activity of acetylcholinesterase, which comprises using extract preparations of leaves, peels, stones, pulp and branches of wampum bark to inhibit the activity of acetylcholinesterase. The invention also discloses a preparation method of the extract preparation and a test method for the inhibition rate of the acetylcholinesterase activity.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method for inhibiting the activity of acetylcholinesterase. Background technique [0002] According to the "2016 World Report on Alzheimer's Disease", there are currently 46.8 million people in the world suffering from AD (Alzheimer's disease). The aging of the world population will further exacerbate this problem and lead to a dramatic increase in the number of AD patients, which is expected to nearly double every 20 years. Thus, the number of people with AD will reach 74.7 million in 2030 and 131.5 million in 2050. AD has become the third leading cause of disability and death in the elderly, second only to cardiovascular and cerebrovascular diseases and malignant tumors. Since the first AD patient was diagnosed, only five drugs have been approved by the FDA for the treatment of AD in the past 100 years. Not only that, but these approved drugs, including cholinesterase inhibito...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61P25/28
CPCA61K36/75A61K2236/333A61K2236/35A61P25/28
Inventor 丁运华黄佳璇
Owner HUIZHOU UNIV
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