Detection method of MRI (magnetic resonance imaging) homonuclear decoupling one-dimensional phase-sensitive localized spectrum

Abstract

The invention provides a detection method of a MRI (magnetic resonance imaging) homonuclear decoupling one-dimensional phase-sensitive localized spectrum and relates to MRS (magnetic resonance spectroscopy). The method comprises the following steps: a to-be-detected sample is placed into a detection chamber of a magnetic resonance imager; the placement position of the sample in the detection chamber is adjusted to enable the sample to be in the center of the detection chamber of the magnetic resonance imager, and then shimming, tuning and power frequency correction are performed; width of radio-frequency pulse enabling magnetization vector of the to-be-detected sample to turn over for 90 degrees is measured; a homonuclear decoupling one-dimensional phase-sensitive spectroscopy pulse sequence is introduced to the magnetic resonance imager, and an ISIS (image-selected in vivo spectroscopy) localization module and a PSYCHE homonuclear decoupling module of the homonuclear decoupling one-dimensional phase-sensitive spectroscopy pulse sequence are opened; experiment parameters of all modules of the homonuclear decoupling one-dimensional phase-sensitive spectroscopy pulse sequence are set, and data sampling is executed; after data sampling completion, sampled data is subjected to postprocessing which includes data splicing, one-dimensional Fourier transform and spectrum peak phase position modulation, and one MRI homonuclear decoupling one-dimensional phase-sensitive localized spectrum is obtained.

Description

technical field [0001] The invention relates to the technical field of nuclear magnetic resonance localization spectroscopy, in particular to a detection method of nuclear magnetic resonance homonuclear decoupling one-dimensional phase-sensitive localization spectroscopy. Background technique [0002] In recent decades, magnetic resonance imaging (Magnetic Resonance Imaging, MRI) technology has made great progress and is widely used in medicine, biology, chemistry, materials, physics and other fields. Magnetic Resonance Spectroscopy (MRS), as an important supplementary tool of MRI technology, is widely used in the detection of living biological tissues. Localized MRS refers to the use of gradient fields and pulse combinations to selectively excite a part of biological tissue components, and then observe the nuclear magnetic resonance signals generated by them, and process the signals of the selected tissue components to obtain corresponding magnetic resonance spectra. MRS t...

AI Technical Summary

Problems solved by technology

Due to the relatively narrow chemical shift distribution range of the one-dimensional hydrogen spectrum (only about 10ppm) and the spectral line splitting caused by J coupling, there is a common phenomenon of spectral peak overlap in the single-pixel one-dimensional localized spectrum, resulting in peak signal cannot be attributed accurately

In addition, due to the interference of local magnetic susceptibility differences in living tissue, even under shimming conditions, it often leads to spectral line broadening and sensitivity reduction, which brings great difficulties to the MRS detection of metabolites in living organisms.

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