A gold nano-cluster particle for intelligently releasing insulin to regulate blood sugar and its preparation method

Abstract

The invention discloses a gold nano-cluster particle for intelligently releasing insulin for regulating blood glucose and a preparation method thereof, and belongs to the technical field of biomedicine. The gold nano-cluster particle comprises carrier materials, glucose response sensitive switch factors and medicine molecules. The preparation method comprises the following steps of firstly preparing the gold nano-cluster particles with rich amino groups on the surface from chloroauric acid, glutathione and CR9 polypeptide through reaction; using the particles as carrier materials of the medicine molecules; activating carboxyls on 4-carboxyphenylboronic acid or 4-carboxyl-3-fluorophenylboronic acid; grafting and modifying 4-carboxyphenylboronic acid or 4-carboxyl-3-fluorophenylboronic acidmolecules onto the surface of the carrier materials to be used as glucose response sensitive switch factors; then, grafting glycosylated insulin onto the surface to obtain the gold nano-cluster particle for intelligently releasing insulin for regulating blood glucose. The gold nano-cluster particle provided by the invention can release insulin according to the glucose concentration; the goal of regulating and controlling the concentration of the glucose is achieved; the blood glucose further recovers to the normal level.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a gold nano-cluster particle for intelligently releasing insulin to regulate blood sugar and a preparation method thereof. Background technique [0002] Diabetes is a group of major chronic metabolic diseases characterized by hyperglycemia. Relative or absolute insufficiency of insulin in the human body leads to hyperglycemia, which is an important cause of diabetes. Diabetes has become the third major factor endangering human health. According to statistics, there were 420 million diabetic patients in the world in 2016, and China is the country with the largest number of diabetic patients. [0003] Real-time monitoring of blood glucose concentration in the body and timely injection of insulin are the keys to effective control of diabetes. At present, the vast majority of diabetic patients are treated with insulin, that is, taking insulin by injection or orally to regulate blood suga...

AI Technical Summary

Problems solved by technology

Long-term frequent subcutaneous insulin injections bring severe psychological pressure to patients and affect their quality of life

At the same time, if the injection dose cannot be accurately controlled, it is easy to cause hyperglycemia or hypoglycemia, which can induce serious complications, or the low blood glucose concentration in the patient's body will endanger life and health.

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