A two-component hydrogel for repairing bone tissue

A hydrogel, two-component technology, used in tissue regeneration, prosthesis, additive processing, etc., can solve the problems of inability to achieve precise and dense bone repair, slow curing of repaired bone, and hindering the healing of bone damage. Achieve improved curing rate and adhesion performance, dense bone repair, good biocompatibility

Active Publication Date: 2021-07-30
山东明河药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] For the currently widely used 3D printing bone tissue molding scheme, it is difficult to effectively hot-melt bond the material, resulting in slow curing of the repaired bone, poor adhesion, and poor biocompatibility, which makes it impossible to achieve precise and dense bone repair, and cannot Long-term storage greatly hinders the healing effect of bone damage. This invention proposes a two-component hydrogel for repairing bone tissue, thereby effectively improving repair efficiency and ensuring a good repair effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The two-component hydrogel is composed of hydrogel A and hydrogel B;

[0033] The mass ratio of hydrogel A and hydrogel B used for printing is 4:3;

[0034] In hydrogel A, each component is: methacryloyl glycinamide hydrogel 45kg, monetite 13kg, calcium sulfate 15kg, nonionic surfactant 0.4kg, ethyl acetate 26.6kg;

[0035] In hydrogel B, each component is: silica gel 28kg, silicic acid 22kg, polylactic acid short fiber 28kg, zwitterionic surfactant 0.4kg, ethanol 21.6kg;

[0036] The nonionic surfactant is coconut oil glucoside; the short polylactic acid fiber is poly d-lactic acid fiber; the zwitterionic surfactant is lecithin;

[0037] The preparation process is:

[0038] (1) In a high-speed mixer, use non-ionic surfactants to treat monetite and calcium sulfate on the surface, add them to ethyl acetate after discharging, stir and disperse evenly, and then mix with methacryloylglycine The amide hydrogel is mixed to obtain stable hydrogel A; the high-speed mixer is ...

Embodiment 2

[0043] The two-component hydrogel is composed of hydrogel A and hydrogel B;

[0044] The mass ratio of hydrogel A and hydrogel B used for printing is 3:2;

[0045] In hydrogel A, each component is: methacryloyl glycinamide hydrogel 40kg, monetite 10kg, calcium sulfate 14kg, nonionic surfactant 0.5kg, ethyl acetate 35.5kg;

[0046] In hydrogel B, each component is: silica gel 22kg, silicic acid 18kg, polylactic acid short fiber 28kg, zwitterionic surfactant 0.2kg, ethanol 31.8kg;

[0047] The nonionic surfactant is lauryl glucoside; the short polylactic acid fiber is poly L-lactic acid fiber; the zwitterionic surfactant is an amino acid active agent;

[0048] The preparation process is:

[0049] (1) In a high-speed mixer, use non-ionic surfactants to treat monetite and calcium sulfate on the surface, add them to ethyl acetate after discharging, stir and disperse evenly, and then mix with methacryloylglycine The amide hydrogel is mixed to obtain stable hydrogel A; the high-sp...

Embodiment 3

[0054] The two-component hydrogel is composed of hydrogel A and hydrogel B;

[0055] The mass ratio of hydrogel A and hydrogel B used for printing is 4:3;

[0056] In hydrogel A, each component is: methacryloyl glycinamide hydrogel 50kg, monetite 15kg, calcium sulfate 17kg, nonionic surfactant 0.4kg, ethyl acetate 17.6kg;

[0057] In hydrogel B, each component is: silica gel 30kg, silicic acid 26kg, polylactic acid short fiber 30kg, zwitterionic surfactant 0.4kg, ethanol 13.68kg;

[0058] The nonionic surfactant is cetearyl glucoside; the short polylactic acid fiber is poly dL-lactic acid fiber; the zwitterionic surfactant is a betaine type active agent;

[0059] The preparation process is:

[0060] (1) In a high-speed mixer, use non-ionic surfactants to treat monetite and calcium sulfate on the surface, add them to ethyl acetate after discharging, stir and disperse evenly, and then mix with methacryloylglycine The amide hydrogel is mixed to obtain stable hydrogel A; the hi...

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Abstract

The invention provides a two-component hydrogel for repairing bone tissue. The two-component hydrogel is composed of hydrogel A and hydrogel B, and the components of hydrogel A are 40-50 parts of methacryloyl glycinamide hydrogel, 10-50 parts of monetite 15 parts, 13-18 parts of calcium sulfate, 0.3-0.6 parts of non-ionic surfactant, 16.4-36.7 parts of ethyl acetate; the components of hydrogel B are 22-30 parts of silica gel, 18 parts of silicic acid ~26 parts, polylactic acid short fiber 25~32 parts, zwitterionic surfactant 0.2~0.5 parts, ethanol 11.5~34.8 parts. The two-component hydrogel can be stored alone for a long time. When used, the two-component hydrogel reacts and crystallizes, which can effectively realize precise and dense bone repair, fast curing rate, good adhesion performance, good biocompatibility, greatly Improves the healing effect of bone injuries.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a two-component hydrogel, in particular to a two-component hydrogel for repairing bone tissue. Background technique [0002] The key to clinical treatment of bone defects caused by trauma, tumors, tuberculosis and congenital developmental deformities is to repair the defective bone tissue and restore normal structure and function. Traditional bone tissue repair includes autologous bone grafting, allograft bone implantation, metal stent or prosthetic implantation, etc. Conventional orthopedic implant materials include metals and non-metals. Metals are mostly used for joints or internal fixation. At present, stainless steel, cobalt-chromium-molybdenum alloys, titanium and titanium alloys are mostly used. The above-mentioned traditional treatments all have disadvantages such as incapable of individualized shaping, stress deformation, and affecting normal bone growth. In recent yea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/02A61L27/18A61L27/50B33Y10/00B33Y70/10
CPCA61L27/025A61L27/12A61L27/16A61L27/18A61L27/50A61L2430/02B33Y10/00B33Y70/00C08L33/24C08L67/04
Inventor 陈庆曾军堂
Owner 山东明河药业有限公司
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