A kind of traditional Chinese medicine formula granule and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine formula granule and a preparation method thereof. The formula granule is composed of the following components: traditional Chinese medicine dry powder, polyethylene glycol and micropowder silica gel. At the same time, the invention also provides another formula granule, which is composed of traditional Chinese medicine dry powder, filler, polyethylene glycol and micropowder silica gel. The invention also provides a preparation method of the granules containing the above formula, which is dry granulation. After repeated tests and continuous exploration, the inventor found that polyethylene glycol was added to the traditional Chinese medicine formula granules as a lubricant, binder, and cosolvent, and after the dosage was screened, it improved the moldability, ensured the particle size, The improvement of the drug loading ratio is significantly improved compared with the ratio of traditional excipients.

Description

technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to a prescription of traditional Chinese medicine formula granules prepared by dry granulation and a process thereof. Background technique [0002] Traditional Chinese medicine formula granules are granules made by extracting and concentrating single-flavored Chinese medicine decoction pieces, and are used for clinical formulas of traditional Chinese medicine. [0003] The active ingredients, nature, taste, meridian distribution, indications, and efficacy of traditional Chinese medicine formula granules are exactly the same as those of traditional Chinese medicine decoction pieces. The feature of reducing weight is better than that of Chinese patent medicine, and it saves the trouble of traditional decoction for patients. At the same time, it can be flexibly taken with single-flavor granules, which is hygienic and effective. [0004] In recent years, Chinese medicine formula gran...

AI Technical Summary

Problems solved by technology

[0014] 1. The material is highly viscous and poor compressibility leads to great differences in particle formability; some decoction pieces and extracts can be directly compressed to make granules, and a large part of traditional Chinese medicine extracts have poor compressibility and low yield at one time. It needs to be pressed repeatedly, or it can be achieved by increasing the pressure of the equipment

[0015] 2. Part of the formula can suppress normal granules, but the particle size and strength of the granules are poor. During the process of handling and extrusion, the granules are easily crushed and a large amount of fine powder is produced.

[0016] 3. For some highly viscous prescriptions, some choose to use insoluble excipients such as magnesium stearate as dry pressing lubricants; this will cause insoluble substances to float on the surface of the solution when the particles dissolve, resulting in poor solubility

[0017] 4. Some Chinese medicine extracts have poor fluidity and very light specific gravity, at 0.2g / cm 3 Left and right, the traditional prescription cannot satisfy the smooth granulation of dry granulation

[0020] 7. The difficulty of traditional Chinese medicine formula granules is: there are many varieties of traditional Chinese medicine formula granules, and there are many types of excipients correspondingly required, which is not convenient for production management

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