Method for preparing dihydrostreptomycin sulfate based on microreactor

A technology of dihydrostreptomycin sulfate and streptomycin sulfate, which is applied in the field of preparation of dihydrostreptomycin sulfate based on microreactors, can solve the problems of high reducing agent consumption, low production efficiency, and potential safety hazards, and it is easier to achieve ash content Qualification, burden reduction, waste reduction effect

Inactive Publication Date: 2017-12-22
HEBEI SHENGXUE DACHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of method based on microreactor to prepare dihydrostreptomycin sulfate, to solve the consumption of reducing agent proposed in the above-mentioned background technology is higher, there is certain potential safety hazard, and the problem of low production efficiency

Method used

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  • Method for preparing dihydrostreptomycin sulfate based on microreactor
  • Method for preparing dihydrostreptomycin sulfate based on microreactor
  • Method for preparing dihydrostreptomycin sulfate based on microreactor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The titer of streptomycin sulfate circulating analysis solution is 174059U / mL, adjust the pH to 6.5 with sodium hydroxide, and enter the microreactor from different flow channels with potassium borohydride solution, and place the microreactor in a water bath at 18°C. Reaction, residence time 10s. The micro-reactor micro-channel section depth of embodiment 1.1 to 1.6 is 0.5 mm, and the width ranges from 1-10 mm. The flow rate of the circulating analytical solution is 10mL / min, and the potassium borohydride solution is controlled to enter the microreactor in different amounts. Table 1.1 is the conversion rate when the different potassium borohydride additions of embodiment 1.1 to 1.6, figure 1 It is embodiment 1.6 product collection of illustrative plates, table 1.2 is peak result chart.

[0025] Table 1.1

[0026]

[0027] Table 1.2

[0028] peak result

[0029]

Embodiment 2

[0032] The titer of streptomycin sulfate circulating analysis solution is 96799U / mL, adjust the pH to 6.75 with sodium hydroxide, enter the microreactor from different flow channels with potassium borohydride solution, and place the microreactor in a water bath at 20°C. Reaction, residence time 10s. The microreactor microchannel section depth of embodiment 2.1 to 2.2 is 0.5mm, and width 1-10mm does not wait. The flow rate of the circulating analytical solution is 10mL / min, and the potassium borohydride solution is controlled to enter the microreactor in different amounts. Table 2.1 is the conversion rate when different potassium borohydride additions are made in Examples 2.1 to 2.2, figure 2 For embodiment 2.2 product collection of illustrative plates, table 2.2 is peak result graph, image 3 It is the product spectrum of Example 2.3, and Table 2.5 is the peak result chart.

[0033] Table 2.1

[0034]

[0035] Table 2.2

[0036] peak result

[0037]

[0038] Table...

Embodiment 3

[0043] The titer of the streptomycin sulfate circulating analysis solution is 13333U / mL, the pH is adjusted to 6.8 with sodium hydroxide, and the potassium borohydride solution enters the microreactor from different flow channels, and the microreactor is placed in a water bath at 17°C. Reaction, residence time 10s. The microreactor microchannel section depth of embodiment 3.1 to 3.2 is 0.5mm, and width 1-10mm does not wait. The flow rate of the circulating analytical solution is 20mL / min, and the potassium borohydride solution is controlled to enter the microreactor in different amounts. Table 3 is the conversion rate when different potassium borohydride additions are made in Examples 3.1 to 3.2.

[0044] table 3

[0045]

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Abstract

The invention discloses a method for preparing dihydrostreptomycin sulfate based on a microreactor in the technical field of production and preparation techniques of semi-synthetic antibiotics. The method for preparing dihydrostreptomycin sulfate based on a microreactor comprises the following steps of S1, pouring sodium hydroxide to sulphuric acid circulating desorption solution of streptomycin sulfate; and S2, pouring a solution obtained through neutralization in step S1 into the microreactor, so that the consumption of a reducing agent is greatly reduced, the utilization rate of the reducing agent is increased, and the waste of the reducing agent is reduced. After the reducing agent namely potassium borohydride dissolves in water, a large amount of hydrogen can be realized, during existing operation, potential safety hazard is easy to cause, and reduction of the consumption of the reducing agent namely the potassium borohydride can increase the security coefficient. The consumption of the reducing agent namely the potassium borohydride is low, the content of potassium ions in a hydrogenated solution is relatively reduced, and the burden of a later-stage desalinating technology is reduced, so that the ash is easy to be qualified.

Description

technical field [0001] The invention relates to the technical field of production and preparation of semi-synthetic antibiotics, in particular to a method for preparing dihydrostreptomycin sulfate based on a microreactor. Background technique [0002] After the aldehyde group of streptomycin in streptomycin sulfate is reduced to primary alcohol, it becomes dihydrostreptomycin. Its antibacterial efficacy is roughly the same as that of streptomycin, but dihydrostreptomycin sulfate can Overcome the problem of poor stability of streptomycin. [0003] Dihydrostreptomycin can be directly fermented by Streptomyces hygroticum, but because dihydrostreptomycin does not contain aldehyde groups, it is difficult to purify the product purity by macroporous adsorption resin or chelating resin. At present, the semi-synthetic method is generally used to prepare dihydrostreptomycin, that is, streptomycin is obtained by fermentation, and then dihydrostreptomycin is obtained by reduction react...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/00C07H15/238
CPCC07H1/00C07H15/238
Inventor 宋志倩耿立民程克雷王勇
Owner HEBEI SHENGXUE DACHENG PHARMA
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