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Complexes of whey protein micelles and pectin and body muscle protein synthesis

A technology of whey protein micelles and whey protein, which is used in the treatment or prevention of diseases related to the reduction of muscle mass or the reduction of muscle protein synthesis rate, and can solve the problems of inability to complete physical activities, reduce the quality of life of patients, and increase the risk of accidents, etc. question

Active Publication Date: 2017-08-29
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Loss of muscle mass and muscle strength can significantly reduce the quality of life of patients with this condition as these patients become unable to perform certain physical activities and the unintended risks associated with such physical activities such as walking Increase

Method used

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  • Complexes of whey protein micelles and pectin and body muscle protein synthesis
  • Complexes of whey protein micelles and pectin and body muscle protein synthesis
  • Complexes of whey protein micelles and pectin and body muscle protein synthesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Preparation of Pectin-Whey Protein Micellar Complex

[0057] Whey protein gels were prepared by heat treating a dispersion (Prolacta 90) of 4 wt% protein, pH 5.89 whey protein isolate (Prolacta 90) at 85°C for 15 min, then microfiltered up to 22 wt% total solids to concentrate and spray dry Beam Powder (WPM).

[0058] A stock solution of 5 wt% pectin (highly methylated pectin, Classic CU201, Herbstreith & Fox KG) was prepared in deionized water by stirring at 60°C for 2-3 hours. In order to fully hydrate the chains, the solution was stirred overnight at 4°C. A 15% by weight stock solution of WPM at pH 3.5 was prepared. First, the powder was dispersed in 135 mM HCl solution overnight at 4 °C. The dispersion was then homogenized twice at 250 bar and once at 50 bar. Final dry matter and subsequent protein concentrations were verified using an HR73 Halogen Moisture Analyzer (Mettler Toledo), and particle size was checked by dynamic light scattering (Zetasiz...

Embodiment 2

[0072] Example 2: Apparent effect of complexes of whey protein micelles and pectin on amino acids

[0073] The inventors monitored the postprandial response of plasma amino acid concentrations in a randomized double-blind crossover study in healthy minipigs. A washout period of at least 6 days was maintained between meals, during which time the minipigs were fed a regular diet.

[0074] Compare the following isocaloric and isonitrogenous meal replacements.

[0075] A

Whey Protein Micellar (WPM) + Lipid + Maltodextrin

B

WPM / Pectin Complex + Lipid + Maltodextrin

[0076] Both meals were approximately 300ml and contained 30g whey protein, 11g lipid and 30g maltodextrin. Meal B also contained 1.5 g of pectin (high methylated pectin, Classic CU201, Herbstreith & Fox KG (Classic CU201, Herbstreith & Fox KG)). The assay measures caloric value and protein content, and adjusts the size of each test meal slightly to ensure they are all isocaloric and ison...

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Abstract

The present invention relates to the treatment or prevention of conditions linked to reduced muscle mass or reduced muscle protein synthesis rate. A subject matter of the invention is a composition comprising complexes of whey protein micelles and pectin for use in the treatment or prevention of a condition selected from the group consisting of sarcopenia, muscle atrophy and negative nitrogen balance. Further aspects of the invention relate to the non-therapeutic use of a composition comprising complexes of whey protein micelles and pectin and a food composition.

Description

technical field [0001] The present invention relates to the treatment or prevention of conditions associated with loss of muscle mass or decreased rate of muscle protein synthesis. A subject of the present invention is a composition comprising a complex of whey protein micelles and pectin for the treatment or prevention of a condition selected from sarcopenia, muscle wasting and negative nitrogen balance. Other aspects of the invention relate to the non-therapeutic use of a composition comprising a complex of whey protein micelles and pectin and a food composition. Background technique [0002] Loss of muscle mass and muscle strength can significantly reduce the quality of life of patients with this condition as these patients become unable to perform certain physical activities and the unintended risks associated with such physical activities such as walking Increase. One can identify two main conditions that lead to loss of muscle mass and muscle strength, one is muscle ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/19A23L29/231A23K20/147A23K20/163A61K38/01A61P21/00A61K35/20A61K31/732
CPCA61K31/732A61K35/20A61K38/018A23V2200/316A23V2200/228A23V2200/00A23V2250/54252A23V2250/5072A61K2300/00A23K20/147A23K20/163A23L33/40A23V2002/00A23L33/19A61P17/02A61P21/00A61P35/00A61P43/00A23L33/30A23L33/21A23C9/1307
Inventor D·布勒耶E·普托S·F·波帕尼塔L·多纳托-卡博尔
Owner SOC DES PROD NESTLE SA
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