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Application of dalbavancin in the preparation of drugs for treating AIDS

A technology for dalbavancin and AIDS, applied in antiviral agents, instruments, glycopeptide components, etc., can solve the problem of the anti-HIV activity of dalbavancin, which has not been seen, and the rapid and accurate prediction and discovery of anti-HIV Active methods and other issues

Active Publication Date: 2019-05-14
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the method of quickly and accurately predicting and discovering the anti-HIV activity of existing drugs in the prior art, and there is no report on the compound dalbavancin having anti-HIV activity

Method used

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  • Application of dalbavancin in the preparation of drugs for treating AIDS
  • Application of dalbavancin in the preparation of drugs for treating AIDS
  • Application of dalbavancin in the preparation of drugs for treating AIDS

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Testing the anti-HIV effects of Dalbavancin:

[0026] 1. Purpose of the experiment: To test the anti-HIV effect of Dalbavancin

[0027] 2. Experimental materials

[0028] 2.1. Determination of Drugs and Compounds

[0029] Dalbavancin was purchased from Beijing Lebo Biotechnology Co., Ltd. The positive control compound azidothymidine (3'-Azido-3'-deoxythymidine, AZT) was purchased from Sigma. The sample to be tested is dissolved in RPMI-1640 complete medium or DMSO according to solubility, the sample stock solution concentration dissolved in DMSO is 50mM, and the sample stock solution concentration dissolved in RPMI-1640 complete medium is 10mM, 5mM or 2mM ( According to the solubility), the storage conditions are: -20°C; AZT is dissolved in RPMI-1640 complete medium, sterilized by filtration with a 0.22 μm filter membrane, the concentration of the stock solution is 6 mg / ml, and stored at -20°C after aliquoting.

[0030] 2.2. Reagents and solutions

[0031] 2.2.1. R...

Embodiment 2

[0061] Add excipients according to the weight ratio of dalbavancin (Dalbavancin) to excipients 1:1 or 1:2, granulate and compress into tablets.

Embodiment 3

[0063] Dalbavancin (Dalbavancin) is an active ingredient, and it is made into capsules according to a conventional capsule preparation method.

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PUM

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Abstract

The invention relates to application of Dalbavancin in preparation of a medicine for curing AIDS, and provides application of Dalbavancin and pharmaceutically acceptable salt thereof in preparation of the medicine for curing AIDS. The experimental result of the anti-HIV activity of Dalbavancin specific to an HIV-1NL4-3 virus strain shows the inhibiting effect of different concentrations of Dalbavancin on the HIV-1NL4-3 virus strain. The EC50 of Dalbavancin that has an inhibiting effect on a syncytium formed through HIV-1 inducing a C8166 cell is 8.694 microns, and the therapeutic index TI is greater than 23.0. A quantitative result in HIV-1p24 antigen shows that the EC50 of Dalbavancin for inhibiting a p24 antigen effect is 1.296 microns, and the therapeutic index TI is greater than 135.1. The experimental result indicates that Dalbavancin has relatively low or no cytotoxicity, possesses remarkable anti-HIV activity and relatively high therapeutic index, and thus can be used for preparing the medicine for curing AIDS.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of compound dalbavancin (Dalbavancin) in the preparation of medicines for treating AIDS. technical background [0002] AIDS is a serious infectious disease caused by Human Immunodeficiency Virus (HIV) infection. As a chronic infectious disease that can directly destroy the human immune system, AIDS has become one of the diseases that seriously threaten human health in the world. According to data from the United Nations Program on AIDS (UNAIDS), as of the end of 2011, a total of 34.2 million people worldwide were infected with HIV. At present, the AIDS epidemic in my country is in a period of rapid growth, with more than 780,000 infected people (UNAIDS, 2011). Therefore, the prevention and treatment of HIV / AIDS has become a social problem and a major scientific research topic that cannot be ignored. The development of new anti-HIV drugs is the mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/14A61P31/18G01N21/31
CPCA61K38/14G01N21/314
Inventor 代绍兴黄京飞陈欢郑永唐李功华李文兴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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