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Compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases as well as preparation method and application thereof

A technology of compound Chinese medicine and colorectal cancer, which is applied in the preparation of compound Chinese medicine composition and the field of inhibiting liver metastasis of colorectal cancer, can solve problems such as the need to improve the effective rate of radiotherapy and the loss of opportunities for surgery, and achieve low production costs and reduce liver cancer. Effect of transfer and improvement of survival rate

Active Publication Date: 2017-02-15
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some patients have already metastasized when the tumor is found, and they lose the chance of surgery
The side effects of chemotherapy often prevent patients from adhering to the final course of treatment, and even after a complete course of chemotherapy, there is only close follow-up and no targeted further treatment; at the same time, due to the dual limitations of equipment and tumor types, the effectiveness of radiotherapy needs improvement

Method used

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  • Compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases as well as preparation method and application thereof
  • Compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases as well as preparation method and application thereof
  • Compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A compound combination drug for reducing colorectal cancer liver metastasis, which consists of the following components in parts by weight:

[0034] 15 parts of roasted astragalus, 15 parts of fried Codonopsis, 10 parts of fried Atractylodes macrocephala, 15 parts of poria cocos, 15 parts of Chinese yam, 5 parts of roasted licorice, 10 parts of sun-burned black plum, 10 parts of trigonum, 10 parts of curcuma, 30 parts of Agrimony, Patrinia 30 parts, altogether 11 medicines.

[0035] According to the proportion of the prescription, weigh the above 11 decoction pieces of traditional Chinese medicine, add water 10 times the total weight of the raw material medicine, decoct and extract 3 times, 1 hour each time. Combined decoction, namely decoction.

[0036] The resulting decoction is concentrated to a relative density of 1.10 (measured at 60° C.), added with ethanol until the alcohol content reaches 60%, and left to stand for more than 12 hours. The supernatant was colle...

Embodiment 2

[0038] A compound combination drug for reducing colorectal cancer liver metastasis, which consists of the following components in parts by weight:

[0039] 15 parts of Radix Astragalus, 30 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 20 parts of Poria cocos, 15 parts of Chinese yam, 5 parts of roasted licorice, 10 parts of sun-baked plum, 15 parts of Sanleng, 15 parts of curcuma, 30 parts of Agrimony, Patrinia 30 parts, altogether 11 medicines.

[0040] According to the proportion of the prescription, weigh the above 11 decoction pieces of Chinese herbal medicines, add 20 times the total weight of raw materials in water, decoct and extract 3 times, 1 hour each time. Combine the decoctions, concentrate to a relative density of 1.08 (measured at 60°C), add ethanol until the alcohol content reaches 60%, let it stand for more than 24 hours, filter the supernatant, recycle the ethanol to the utmost, and concentrate to a relative density of about 1.08 ( meas...

Embodiment 3

[0042] A compound combination drug for reducing colorectal cancer liver metastasis, which consists of the following components in parts by weight:

[0043] 20 parts of Radix Astragalus, 20 parts of Codonopsis pilosula, 15 parts of Atractylodes macrocephala, 15 parts of Poria, 15 parts of Chinese yam, 10 parts of roasted licorice, 15 parts of sun-baked plum, 10 parts of Sanleng, 10 parts of Curcuma, 15 parts of Agrimony, Patrinia 15 parts, totally 11 medicines.

[0044] According to the proportion of the prescription, weigh the above 11 decoction pieces of traditional Chinese medicine, add 5 times the total weight of the raw material in water, decoct and extract 3 times, 1 hour each time. Combine the decoctions, concentrate to a relative density of 1.10 (measured at 60°C), add ethanol until the alcohol content reaches 60%, let it stand for more than 24 hours, filter the supernatant, recycle the ethanol to the utmost, and concentrate to a relative density of about 1.33 ( measur...

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Abstract

The invention provides a compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases. The compound traditional Chinese medicine composition is prepared from the following components in parts by weight: 15 to 30 parts of prepared radix astragali seu hedysari, 15 to 30 parts of fried radix codonopsis, 10 to 20 parts of fried bighead atractylodes rhizome, 15 to 30 parts of poria cocos, 15 to 30 parts of rhizoma dioscoreae, 5 to 10 parts of prepared liquorice root, 10 to 20 parts of prepared fructus mume, 10 to 20 parts of rhizoma sparganii, 10 to 20 parts of curcuma zedoary, 15 to 30 parts of herba agrimoniae and 15 to 30 parts of herba patriniae. The invention further discloses a preparation method of the compound traditional Chinese medicine composition and application of the compound traditional Chinese medicine composition to preparation of medicines for treating the colorectal liver metastases.

Description

technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to a compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer and its preparation method and application. Background technique [0002] Malignant tumor is one of the common chronic non-communicable diseases in the world. Surgery, chemotherapy, radiotherapy and biological therapy are the conventional methods for treating tumor patients in medicine. However, some patients have already metastasized when the tumor is found, and they lose the opportunity for surgery. The side effects of chemotherapy often prevent patients from adhering to the final course of treatment, and even after a complete course of chemotherapy, there is only close follow-up and no targeted further treatment; at the same time, due to the dual limitations of equipment and tumor types, the effectiveness of radiotherapy needs improvement. Biological therapy is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/04A61K31/513
CPCA61K31/513A61K36/076A61K36/284A61K36/344A61K36/481A61K36/484A61K36/73A61K36/736A61K36/84A61K36/8945A61K36/902A61K36/9066A61K2236/331A61K2236/333A61K2236/51A61K2300/00
Inventor 周锦勇刘沈林陈玉根朱学军
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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