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A neuroprotective agent

A neuroprotective agent and solvent technology, applied in the field of neuroprotective agents, can solve the problems of no nerve cell protective agent, no neurological function recovery treatment drugs, etc.

Active Publication Date: 2017-02-08
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there are no other effective nerve cell protective agents, and no therapeutic drugs that can promote the recovery of neurological function, except for the very limited clinical time window of the drugs for the treatment of stroke.

Method used

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  • A neuroprotective agent
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Experimental program
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Embodiment

[0046] 1. Detect the high-level endogenous presence of (-)-PA in the brain of mice

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Abstract

The invention relates to a neuroprotective agent. The neuroprotective agent comprises a chemical compound having a structure formula shown as follows. The chemical compound having the structure formula can reduce cell calcium influx through a glutamate receptor invertibility inhibiting function, thus protecting cortical neurons from excitatory toxicity initiated by glutamic acid. The neuroprotective agent is extremely effective.

Description

Technical field [0001] The present invention relates to the field of medicine, in particular to a neuroprotective agent. Background technique [0002] Stroke has become one of the three major diseases that seriously endanger human health. However, at present, there are no effective neuroprotective agents for the clinical treatment of stroke except for the extremely limited thrombotic drugs used in the clinical time window, and no therapeutic drugs that can promote the recovery of nerve function. Despite decades of efforts, the understanding of endogenous neuroprotective molecules and mechanisms induced by stroke is still limited (Molecular mechanisms of cerebralischemia-induced neuronal death. Hou ST, MacManus JP (2002), Int Rev Cytol 221:93 -148.; The science of stroke:mechanisms in search of treatments.Moskowitz MA,LoEH,Iadecola C(2010).Neuron67:181-198). [0003] Phaseic Acid (PA) is a catabolism product of terpenoids of Abscisic Acid (ABA). ABA is catalyzed by cytochrome P-45...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K47/42A61P25/00A61P9/10
CPCA61K31/343A61K47/42A61P9/10A61P25/00
Inventor 侯圣陶
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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