Separation and extraction method of cytisine

A kind of technology of genistein and extraction method, applied in the field of medicine

Inactive Publication Date: 2016-12-07
西安岳达生物科技股份有限公司
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  • Abstract
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Problems solved by technology

[0003] The object of the present invention is to provide a kind of separation and extraction method of cytisine, to solve the problem of high purity obtained quickly in industrialization

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  • Separation and extraction method of cytisine
  • Separation and extraction method of cytisine
  • Separation and extraction method of cytisine

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Embodiment Construction

[0014] The separation and extraction method of a kind of cytisine: take 3Kg of dried and pulverized whole herb of lanceolus chrysanthemum, extract 3 times with methanol with a plastid ratio of 1:5, combine the extracts, concentrate to no alcohol, Viscous, under neutral pH conditions, extract twice with 3Kg chloroform, discard the lower chloroform phase, adjust the upper aqueous phase to pH = 12 with aqueous sodium hydroxide solution, extract 3 times with 3.8kg chloroform , combined the chloroform phase of the lower layer and concentrated to dryness to obtain 33g of cytisine crude product, which was then dissolved in 0.5L ethyl acetate, eluted with ethyl acetate through alumina column chromatography, tracked and monitored by TLC, and the target substance was collected and concentrated To dryness, recrystallize with 0.25L acetone to obtain 25g of pure product with a content of 99%. ,

[0015] attached figure 1 It is the schematic diagram of LC-MS of the final pure product of t...

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Abstract

The invention discloses a separation and extraction method of cytosine and belongs to the technical field of medicine and chemical engineering. The content of cytosine in the whole herb of a thermopsis lanceolata plant reaches 0.6%-1.5%. The used raw material is thermopsis lanceolata, the industrial production cost is reduced in the aspect of the raw material, column chromatography after extraction is adopted, and cytosine with the purity reaching 99% is obtained rapidly through recrystallization. The invention develops the separation and extraction method of cytosine. The industrial production cost is reduced, the purity reaches the level of a bulk drug, and the production efficiency is improved.

Description

technical field [0001] The invention relates to a method for separating and extracting cytisine, which belongs to the technical fields of medicine and chemical industry. Background technique [0002] Cytisine is derived from the whole plant of the plant Coniferus chinensis. The plant contains a variety of alkaloids, among which cytisine has the highest relative content, accounting for about half of the total alkaloid content. Cytisine has high medicinal value and is an important raw material for the pharmaceutical industry. Domestic research on the insect resistance, physiological activity and toxicity of cytisine has been reported, but there are few reports on its extraction and purification. The invention adopts a common and simple operation method to extract and purify cytisine with the raw material of the whole plant of Huanghua lanceolus, and has the advantages of low cost, short time consumption and high yield, and at the same time, the purity reaches more than 99% of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/22
CPCC07D471/22
Inventor 胡晓安马鹏飞杨晓莉奚文祥张天
Owner 西安岳达生物科技股份有限公司
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