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Application of radix astragali and radix angelica sinensis pharmaceutical composition in preventing vascular intimal hyperplasia

A composition, the technology of angelica, applied in the prevention and treatment of vascular intimal hyperplasia, the field of astragalus and angelica pharmaceutical composition, can solve the problems of restricting clinical application, and achieve the effect of enriching the theory of compatibility

Inactive Publication Date: 2016-12-07
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But what proportion of astragalus and angelica can achieve the best effect of anti-vascular intimal hyperplasia? In the actual clinical application, how should the two drugs be compatible to achieve the effect of nourishing qi, activating blood and resisting vascular intimal hyperplasia? There are different opinions on these problems, which restricts its clinical application.

Method used

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  • Application of radix astragali and radix angelica sinensis pharmaceutical composition in preventing vascular intimal hyperplasia
  • Application of radix astragali and radix angelica sinensis pharmaceutical composition in preventing vascular intimal hyperplasia
  • Application of radix astragali and radix angelica sinensis pharmaceutical composition in preventing vascular intimal hyperplasia

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Embodiment 1

[0032] Application of the medicinal composition of astragalus and angelica in the prevention and treatment of vascular intimal hyperplasia, the compatibility ratio of the astragalus and angelica is 0:1. The preparation method of the Radix Astragali and Angelica medicinal composition is as follows: take raw medicine decoction pieces in proportion, extract three times by hydrothermal reflux method, combine the extracts, concentrate under vacuum and reduce pressure to obtain extracts, and add 0.1% sodium benzoate to the extracts , and then aliquoted and stored at -4 ° C, that is.

Embodiment 2

[0034] The application of the medicinal composition of astragalus and angelica in the prevention and treatment of vascular intimal hyperplasia, the compatibility ratio of the astragalus and angelica is 1:2. Its preparation method is with embodiment 1.

Embodiment 3

[0036] Application of the astragalus and angelica medicinal composition in preventing and treating vascular intimal hyperplasia, the compatibility ratio of the astragalus and angelica is 1:5. Its preparation method is with embodiment 1.

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Abstract

The invention discloses application of a pharmaceutical composition prepared from radix astragali and radix angelica sinensis in preventing vascular intimal hyperplasia. The compatibility proportion of radix astragali to radix angelica sinensis is 1:2 or 1:5 or 1:1 or 5:1. Extract of effective ingredients of radix astragali is adopted, and the radix astragali extract is radix astragali water extract. Extract of effective ingredients of radix angelica sinensis is adopted, and the radix angelica sinensis extract is radix angelica sinensis water extract. According to the application, the compatibility action proportion and the optimal proportion of radix astragali to radix angelica sinensis in vascular intimal hyperplasia resistance are determined, medication guidance is provided for clinical cardiovascular diseases of the same kind, the traditional compatibility proportion of radix astragali to radix angelica sinensis is broken through, and the Chinese medicinal formula compatibility theory is enriched.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, and more specifically relates to the application of a medicinal composition of astragalus and angelica in preventing and treating vascular intimal hyperplasia. Background technique [0002] "Vascular intimal hyperplasia" is the common pathophysiological basis of cardiovascular diseases such as hypertension and restenosis after angioplasty. The pathogenesis of vascular intimal hyperplasia is very complicated, but there are not many drugs with good curative effect. Since the pathological mechanism of vascular intimal hyperplasia is multi-pathway and multi-link, the value of single-target therapy is limited. However, traditional Chinese medicine and compound prescriptions have multi-component, multi-target, and multi-channel overall regulation effects, which can affect vascular intimal hyperplasia from multiple links. Therefore, it is of great scientific significance to find a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P9/14
CPCA61K36/481A61K36/232A61K2236/331A61K2236/39A61K2300/00
Inventor 邓常清黄小平彭熙炜阎卉芳
Owner HUNAN UNIV OF CHINESE MEDICINE
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