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Bayes method for joint estimation of continuous traits and threshold traits based on genomic estimated breeding value

A technique for joint estimation and breeding value, applied in the Bayesian field, which can solve problems such as lack of joint analysis

Inactive Publication Date: 2016-10-12
INST OF ANIMAL HUSBANDRY & VETERINARY MEDICINE ANHUI ACAD OF AGRI SCI
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AI Technical Summary

Problems solved by technology

However, joint analysis of continuous and threshold traits is lacking

Method used

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  • Bayes method for joint estimation of continuous traits and threshold traits based on genomic estimated breeding value
  • Bayes method for joint estimation of continuous traits and threshold traits based on genomic estimated breeding value
  • Bayes method for joint estimation of continuous traits and threshold traits based on genomic estimated breeding value

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Embodiment Construction

[0061] This example proposes a new Bayesian method based on the line-threshold model, called LT-BayesCπ, for joint analysis of continuous traits and threshold traits.

[0062] 1. Method

[0063] 1.1 Model

[0064] let y′ 1 ={y 1,i}(i=1,2,…,n) is the vector of observation values ​​of continuous traits, y′ 2 ={y 2,i}(i=1,2,…,n) is the threshold trait observation value vector, l′={l i}(i=1,2,...,n) is the latent variable vector associated with the threshold trait. line-threshold model [15] for:

[0065] where β 1(2) is the fixed effect vector; g 1(2) is the SNP effect vector; e 1(2) is the random residual vector; X 1(2) for β 1(2) The correlation matrix of ; Z is the genotype indicator matrix (the assignments 0, 1, and 2 correspond to 11, 12, and 22 of the genotype, respectively). Let v'=[y' 1 , l′], given β and g, v obeys the following distribution:

[0066] v | β , g , R ...

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Abstract

The invention discloses a bayes method for joint estimation genomic of continuous traits and threshold traits based on genomic estimated breeding value. The bayes method is a new bayes method based on a line-threshold model, called as LT-BayesC pi used for joint estimation of continuous traits and threshold traits. Simulation data and the fourteenth QTL-MAS international symposium public data are used for verifying LT-VayesC pi. Accuracy of genomic prediction and BayesC pi and Bayes TCpi based on a single character model are compared. Factors influencing performance representations are also researched. The result of the bayes method shows that genomic prediction of threshold traits with LT-BayesCpi is more accurate than that with BayesTCpi. However, accuracy of continuous traits is the same as that of BayesCpi.

Description

technical field [0001] The invention relates to a Bayesian method for jointly estimating the genome breeding value of continuous traits and threshold traits. Background technique [0002] With the development of single nucleotide polymorphism (SNP) chips and genotype sequencing technologies, many genome-wide polymorphisms have been used in animal and plant breeding practices. Genome selection can use the whole genome marker information to predict the genetic value of breeding stock without the phenotype information of the individual itself. In the classical genome prediction process, the SNP effects are first estimated using individual composition parameters with both genotype and phenotype information, and then these estimated effects are used to construct prediction equations to calculate their genomic breeding values ​​based on the genotypes of candidate individuals (GEBVs). Therefore, in genomic selection, a suitable model is the key to accurately predict genomic breed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/24
CPCG16B40/00
Inventor 王重龙丁向东李秀金钱蓉张勤
Owner INST OF ANIMAL HUSBANDRY & VETERINARY MEDICINE ANHUI ACAD OF AGRI SCI
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