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A method for preparing nanorod crystal hydroxyapatite hydrosol

A technology of crystalline hydroxyapatite and hydroxyapatite, which is applied in the field of synthesis of nano-biological ceramics, can solve the problems of strict reaction conditions, etc., and achieve the effect of rich sources, fine grains, and increased nucleation rate

Active Publication Date: 2018-05-04
杭州纳美智康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The quality of the product obtained by this method is stable and the process is repeated, but the reaction needs to be carried out in a high-pressure reactor, and the reaction conditions are relatively strict.

Method used

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  • A method for preparing nanorod crystal hydroxyapatite hydrosol
  • A method for preparing nanorod crystal hydroxyapatite hydrosol

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 1) prepare the mixed solution of calcium nitrate and calcium chloride of 0.1M, add citric acid, form mixed solution A; Prepare the mixed solution B of 0.1M potassium phosphate and ammonium phosphate; Calcium ion in two kinds of solutions: phosphate ion: lemon The molar ratio of acid radical ion is 1:0.67:1;

[0025] 2) Slowly add the above-mentioned mixed solution A into the solution B at a rate of 0.5ml / min, and stir while dropping to form a mixed solution C. After the addition, add ammonia water to adjust the pH of the solution to 9, and fully react Afterwards, the mixed solution C was aged at room temperature for 24h;

[0026] 3) The above-mentioned aged mixed solution C was stirred again at high speed for 1.5 h, aged for 24 h, and repeated 2 times;

[0027] 4) Use a high-speed centrifuge to centrifuge the above solution to obtain a precipitate, use deionized water and absolute ethanol to alternately centrifuge and wash the precipitate 4 times to remove excess elect...

Embodiment 2

[0030] 1) Prepare 0.5M calcium nitrate solution, add citric acid to form mixed solution A; prepare 0.5M ammonium phosphate solution B; in the two solutions, calcium ion: phosphate ion: the molar ratio of citrate ion is 1:0.67:0.7 ;

[0031] 2) Slowly add the above-mentioned mixed solution A into the solution B at a rate of 1ml / min, and stir while dropping to form a mixed solution C. After the addition is completed, add ammonia water to adjust the pH value of the solution to 11, and fully react Afterwards, the mixed solution C was aged at room temperature for 24h;

[0032] 3) The above-mentioned aged mixed solution C was stirred again at high speed for 2 hours, aged for 24 hours, and repeated twice;

[0033] 4) Use a high-speed centrifuge to centrifuge the above solution to obtain a precipitate, use deionized water and absolute ethanol to alternately centrifuge and wash the precipitate twice to remove excess electrolyte in the system, and obtain a crystal with a diameter of 5-...

Embodiment 3

[0036] 1) prepare the mixed solution of 0.3M calcium nitrate and calcium acetate, add citric acid, form mixed solution A; prepare the mixed solution B of 0.3M ammonium phosphate and potassium phosphate; calcium ion in two kinds of solutions: phosphate ion: citrate ion The molar ratio is 1:0.67:1.2;

[0037] 2) Slowly add the above-mentioned mixed solution A into the solution B at a rate of 0.8ml / min, and stir while dropping to form a mixed solution C. After the addition, add ammonia water to adjust the pH value of the solution to 10, and fully react Afterwards, the mixed solution C was aged at room temperature for 24h;

[0038] 3) The above-mentioned aged mixed solution C was stirred again at high speed for 1 h, aged for 24 h, and repeated 2 times;

[0039] 4) Use a high-speed centrifuge to centrifuge the above solution to obtain a precipitate, and use deionized water and absolute ethanol to alternately centrifuge and wash the precipitate 3 times to remove excess electrolyte ...

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Abstract

A method of preparing nanorod crystal hydroxylapatite hydrosol is provided. The method includes 1) preparing a soluble calcium salt solution having a concentration of 0.1-0.5 M, adding citric acid to form a mixed solution A, and preparing a soluble phosphate solution B having a concentration of 0.1-0.5 M, 2) adding dropwise the solution A into the solution B, stirring to form a mixed solution C, adding ammonia water to adjust the pH value of the solution to be 9-11, reacting at room temperature, and ageing the mixed solution C at room temperature for at least 24 h, 3) stirring the obtained mixed solution C for at least 1 h, and ageing, 4) centrifuging the solution to obtain a precipitate, and centrifuging and washing the precipitate with deionized water and absolute ethyl alcohol to obtain hydroxylapatite nanorods, and 5) dispersing the nanorods into deionized water to form a dispersion having a concentration of 10-20 wt% to obtain the nanorod crystal hydroxylapatite hydrosol. The method has characteristics of nontoxic raw materials, a low cost, a simple synthetic process, easy implementation, stable product quality and good process repeatability, and has a good application prospect in the fields of biomedical materials, coating materials, and the like.

Description

technical field [0001] The invention relates to a method for preparing nano-rod crystal hydroxyapatite hydrosol, which belongs to the field of synthesis of nano-biological ceramics. Background technique [0002] Hydroxyapatite is the most stable calcium phosphate phase in living organisms. This compound is often used to represent hard tissue mineral components such as bone and teeth because of its excellent biocompatibility and bioactivity, as well as its strong ion exchange capacity. Synthetic hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ), especially nanoparticles, have similar properties to natural bone, so it has a very wide range of applications in fields such as bone tissue engineering, heavy metal ion adsorption, protein adsorption, and drug release. However, due to the ultra-high specific surface area of ​​nanoparticles, they are very easy to agglomerate, which greatly limits the application and development of hydroxyapatite in related fields. Therefore, nano-hyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C01B25/32C01P2002/72C01P2004/04C01P2004/16C01P2004/64
Inventor 刘斌姚义俊周凯饶伟锋陈卓赵俊杰陈顺江张诗雨张旭良
Owner 杭州纳美智康科技有限公司
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