Disease susceptibility risk prediction method and device

Abstract

The invention relates to bioinformatics and provides a disease susceptibility risk prediction method and device. The disease susceptibility risk prediction method comprises the steps: providing a database including disease morbidity data, SNP locus genotype frequency data, and risk allele homozygous and heterozygous genotype OR value data aiming at each disease-associated SNP locus; receiving information of a to-be-predicted individual; calculating to obtain a comprehensive disease susceptibility risk array of diseases interested by the to-be-predicted individual; and generating a comprehensive disease susceptibility risk dynamic change curve of the individual in an appointed age range. According to the disease susceptibility risk prediction method and device, two factors , including individual inheritance and environment factors, are considered at the same time when the disease susceptibility risk of an individual is calculated, so that calculating results greatly conform to objective reality; according to the obtained disease susceptibility risk age change curve of the individual, the individual not only can learn more precise immediate disease susceptibility risk, but also can continuously understand the susceptibility change tendency of various diseases along with the growth of age.

Description

technical field [0001] The invention relates to bioinformatics, in particular to a method and device for predicting disease susceptibility risk. Background technique [0002] Some chromosomal loci related to the occurrence of diseases corresponding to genetic constitutions that are unfavorable to health are called disease susceptibility loci, and the so-called disease susceptibility refers to the tendency to suffer from a certain type of disease determined by genetics , People with disease susceptibility must have specific genetic characteristics, simply speaking, they have a susceptibility genotype for a certain disease. So far, in the process of medical statistics research in the past ten years, a large number of chromosomal loci have been found to be closely related to the susceptibility of tumors, cardiovascular and cerebrovascular diseases, chronic diseases and other diseases, and have been repeatedly confirmed by independent studies. For a specific disease, the suscep...

AI Technical Summary

Problems solved by technology

Currently known individual disease susceptibility risk calculation methods are only based on the single nucleotide polymorphism changes of individual chromosome loci, which overemphasizes the importance of genetic information on the occurrence of diseases and ignores the joint effect of "environmental factors and personal genetic constitution". leading to the occurrence of diseases", which leads to the low referenceability of prediction data

Images