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A method for determining the composition of solvents in e-cigarette liquid by gas chromatography-mass spectrometry

A technology of gas chromatography mass spectrometry and e-cigarette liquid, which is applied in the field of e-cigarettes, can solve the problems of inaccurate qualitative and other problems, and achieve the effects of high sensitivity, good linear relationship and accurate detection results

Active Publication Date: 2017-01-04
CHINA TOBACCO ZHEJIANG IND
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Problems solved by technology

[0004] It has been reported that the content of 1,2-propanediol, menthol, diethylene glycol, propylene glycol and triethylene glycol in e-cigarette liquid can be simultaneously determined by gas chromatography, but the gas chromatography is only qualitative by retention time, which is not accurate enough, and there are some problems. limitations

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  • A method for determining the composition of solvents in e-cigarette liquid by gas chromatography-mass spectrometry
  • A method for determining the composition of solvents in e-cigarette liquid by gas chromatography-mass spectrometry
  • A method for determining the composition of solvents in e-cigarette liquid by gas chromatography-mass spectrometry

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Embodiment 1

[0041] The instruments and reagents used in this embodiment are as follows:

[0042] Instrument: Agilent7890B / 5977A gas chromatography-mass spectrometer (Agilent, USA), equipped with autosampler, chemical workstation; XP205 electronic balance (sensitivity: 0.0001g, Mettler-Toledo, Switzerland).

[0043] Reagents: ethanol, 1,2 propanediol, glycerol, diethylene glycol, tetraethylene glycol, pentaethylene glycol (purity>98%, Sigma-Aloririch, USA), triethylene glycol (purity>99%, TCI Japan) , 1,3-butanediol (purity 97.9%, American Chem-Service Company), methanol (chromatographically pure, American Dikma Company).

[0044] A method for determining the composition of solvents in electronic cigarette liquid by gas chromatography-mass spectrometry, comprising the following steps:

[0045] (1) Preparation of internal standard solution

[0046] Using 1,3-butanediol as the solute and methanol as the solvent, prepare an internal standard solution with a concentration of 500 μg / mL.

[0...

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Abstract

The invention discloses a method for measuring solvent compositions in nicotine liquid by combining gas chromatography and mass spectrometry. The method comprises the following steps of preparing a series of standard solutions simultaneously containing ethanol, 1,2-propylene glycol, glycerin, diethylene glycol, triethylene glycol, tetraethylene glycol and pentaethylene glycol by taking a methanol solution of 1,3-butylene glycol as an internal standard solution which serves as a solvent, detecting the series of standard solutions by utilizing gas chromatography-mass spectrometer, and establishing a standard curve; pre-treating the nicotine liquid to obtain a sample solution to be detected, detecting the sample solution to be detected by utilizing the gas chromatography-mass spectrometer, and calculating the solvent compositions in the nicotine liquid according to the corresponding standard curve. According to the method, ethanol, 1,2-propylene glycol, glycerin, diethylene glycol, triethylene glycol, tetraethylene glycol and pentaethylene glycol in a smokeless tobacco product can be simultaneously detected, and the method is easy to operate and high in sensitivity and reproducibility.

Description

technical field [0001] The invention relates to the technical field of electronic cigarettes, in particular to a method for measuring solvent composition in electronic cigarette liquid by gas chromatography-mass spectrometry. Background technique [0002] With the continuous strengthening of the government's tobacco control measures, new tobacco products have gradually become popular. Whether it is used for smoking cessation or as a substitute for traditional cigarettes, e-cigarettes have huge room for growth. E-cigarette is a portable electronic atomizer imitating cigarettes. Through the atomizer, the e-cigarette liquid is made into mist and inhaled directly. The process is similar to smoking real cigarettes. [0003] At present, domestic scholars have carried out relevant research work in the fields of e-cigarette formula, component analysis, and toxicology. Solvent is the main component of e-cigarette liquid. At present, the solvents used in e-cigarette liquid mainly inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 储国海周国俊卢昕博蒋健胡安福尹洁戴路徐建沈凯李霞刘金莉
Owner CHINA TOBACCO ZHEJIANG IND
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