Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Histone deacetylases inhibitor

A technology of deacetylase and histone, applied in the field of medicine

Inactive Publication Date: 2015-07-08
孙勇
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Current research focuses on the chemical modification and structural modification of existing anti-tumor drugs with HDACs inhibitory activity, in order to enhance their efficacy and reduce side effects, etc., and design drugs that act on specific targets from the structural characteristics and biological functions of HDACs. There are still a few anti-tumor drugs with specific pathways

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Histone deacetylases inhibitor
  • Histone deacetylases inhibitor
  • Histone deacetylases inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] One, synthesis embodiment

[0011] 1. Synthesis process: as shown in Figure 1.

[0012] 2. Experimental operation

[0013] (1) Synthesis of 2,5-dichloro-2,5-dimethylhexane

[0014] 2,5-Dimethyl-2,5-hexanediol (7.31g, 50mmol) was added to 12mol / L hydrochloric acid (60ml), heated to 85°C and stirred for 1h, cooled to room temperature, filtered with suction, and the filter cake was dissolved in Dichloromethane, washed with water until neutral, dried over anhydrous magnesium sulfate, filtered, the filtrate was evaporated to remove dichloromethane, and the residue was dried at room temperature under reduced pressure (0.7-13.3Pa) to obtain a white powdery solid 2,5-bis Chloro-2,5-dimethylhexane (7.50 g, 81.88%).

[0015] (2) 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene

[0016] Add 2,5-dichloro-2,5-dimethylhexane (7.32g, 40mmol) to benzene (80ml, 900mmol), add anhydrous aluminum chloride (0.53g, 4mmol) under stirring, and heat The reaction solution was refluxed for ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a histone deacetylases (HDACs) inhibitor compound N<1>-(6-(hydroxyamino)-6-oxohexyl)-N<4>-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)terephthalamide having an obvious inhibitory effect on both HDACs and human leukemia U937 cell growth and proliferation, wherein the inhibitory effect is significantly stronger than that of a common HDACs inhibitor trichostatin TSA. The invention also provides a preparation method and a process route of the compound.

Description

Technical field [0001] The invention relates to a histone deacetylase inhibitor and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Tumor occurrence is a complex pathological process, affected by multiple factors, including individual genetic factors, environmental factors, physical and chemical factors, molecular biological factors and so on. With the rapid development of life sciences and the in-depth development of molecular biology research on the pathogenic mechanism and pathogenesis of tumors, the prominent role of molecular biological factors in tumorigenesis has been gradually revealed. The inactivation of various factors regulating growth and proliferation becomes the key inducement of tumorigenesis. Therefore, the study of molecular biology on the pathogenicity and pathogenesis of tumors provides a basis for the development of low-toxicity and high-efficiency anti-tumor drugs targeting specific molecular targets [Xie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C259/06A61P35/00
Inventor 孙勇徐平沈若武袁海成李红梅
Owner 孙勇
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com