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Malignant-tumour-resistant graphene oxide nano-drug delivery system and preparation method thereof

A nano-drug loading and anti-tumor drug technology, which is applied in the direction of pharmaceutical formulations, organic active ingredients, and medical preparations of non-effective ingredients, can solve the problems of low anti-tumor treatment efficiency and achieve good anti-tumor effects and less toxic side effects , the effect of simplifying steps

Inactive Publication Date: 2015-03-25
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

Although this method increases the drug loading, it only combines dr...

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  • Malignant-tumour-resistant graphene oxide nano-drug delivery system and preparation method thereof
  • Malignant-tumour-resistant graphene oxide nano-drug delivery system and preparation method thereof
  • Malignant-tumour-resistant graphene oxide nano-drug delivery system and preparation method thereof

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Embodiment Construction

[0034] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to Examples described below.

[0035] Step 1: Preparation of Carboxylated Graphene Oxide Nanoparticles

[0036] In an inert gas atmosphere, add 400 μL sodium hydroxide dilute solution (2.5×10 -6 M), after ultrasonication for 2 hours, add 1 mg of sodium chloroacetate solid, continue ultrasonication for 1 hour, and then stir for 24 hours. Adjust the pH value of the reaction solution to neutral with dilute hydrochloric acid, then use dialysis to remove impurities, and vacuum-dry to obtain carboxylated graphene oxide nanoparticles.

[0037] Step 2: Carboxylated Graphene Oxide Nanoparticles Modified with C...

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Abstract

The invention discloses a malignant-tumour-resistant graphene oxide nano-drug delivery system and a preparation method thereof. The preparation method disclosed by the invention comprises the following steps of: carrying out carboxylation of the surface of graphene oxide at first, and modifying graphene oxide by utilizing carboxyl polyoxamide to improve biocompatibility; grafting tumour targeted molecular containing amino on the surface of graphene oxide by a chemical bond through carboxamide condensation reaction mediated by an activating agent; and loading hydrophobic tumour-resistant medicine molecule containing a pi bond by utilizing pi-pi conjugate action. Carboxyl graphene oxide nano-particles have the light absorbing property in a near infrared region; therefore, absorbed light can be converted into heat; and then, a functional graphene oxide nano-material having photothermal, targeting and drug delivery properties can be prepared. Compared with the prior art, the functional graphene oxide nano-material is good in biocompatibility and can be prepared in a large scale; the drug delivery method is simple; and furthermore, the drug delivery amount for hydrophobic medicines is high.

Description

technical field [0001] The invention relates to a nano-drug loading system and a preparation method thereof, in particular to an anti-malignant tumor graphene oxide nano-drug loading system and a preparation method thereof, belonging to the technical field of materials and biomedicine. Background technique [0002] The emergence and rapid development of nanotechnology has provided a new research direction for the treatment of tumors, especially multifunctional nanoparticles, which can combine photothermal therapy with drug loading and targeting to form an efficient and less side effect treatment plan. Drug loading with nanoparticles can improve the solubility of poorly water-soluble drugs, and can target drug delivery in a cell- or tissue-specific manner (Angew.Chem.2011, 123, 7723-7728), and can also pass through tight epithelial cells. Or endothelial barrier drug transcellular transport, and even carry multiple drugs at the same time and achieve the transport of macromolec...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/585
Inventor 张亚非李晓琳杨志魏良明鲁得泂
Owner SHANGHAI JIAO TONG UNIV
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