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Application of amprenavir in preparation of medicine for preventing or treating ischemic cardiovascular and cerebrovascular diseases

A cardiovascular and cerebrovascular disease, ischemic technology, applied in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as unreported pharmacological effects and increased CD4 cell counts

Inactive Publication Date: 2014-10-01
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term application of amprenavir can reduce HIV viral load in blood and increase CD 4 The count of cells can reduce the chance of AIDS infection, improve the quality of life, and prolong life, but the pharmacological effects of amprenavir in the prevention or treatment of ischemic cardiovascular and cerebrovascular diseases have not been reported

Method used

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  • Application of amprenavir in preparation of medicine for preventing or treating ischemic cardiovascular and cerebrovascular diseases
  • Application of amprenavir in preparation of medicine for preventing or treating ischemic cardiovascular and cerebrovascular diseases
  • Application of amprenavir in preparation of medicine for preventing or treating ischemic cardiovascular and cerebrovascular diseases

Examples

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Embodiment 1

[0012] Example 1 Preparation of Amprenavir Tablets

[0013] Weigh 120.0g amprenavir, and 120.0g carboxymethyl starch sodium, mix well and pass through a 100 mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to prepare soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add 2.0g of magnesium stearate, mix evenly and press into tablets, adjust the weight of the tablet to about 240mg to obtain the product.

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Abstract

The invention relates to a novel application of a medicine, and in particular relates to the novel application of amprenavir for preventing or treating ischemic cardiovascular and cerebrovascular diseases by inhibiting an expression of HMGB1 (High Mobility Group Box 1). During the application, the dosage of the amprenavir is controlled within 120mg to 6000mg, wherein the amprenavir within the dosage of 240mg to 3000mg is optimally selected.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to amprenavir preventing or treating ischemic cardiovascular and cerebrovascular diseases by inhibiting the expression of HMGB1. Background technique [0002] Ischemic stroke is a major disease that seriously endangers human health. Theoretical treatment methods include: (1) Thrombolytic therapy within 3-6 hours after onset. (2) Neuroprotective treatment of secondary nerve damage caused by ischemia. (3) Nerve repair promotes synaptic remodeling and regeneration of surviving nerve cells, including neuroregeneration and neurogenesis. Early thrombolytic therapy is currently recognized as the most effective method, but the treatment time window is narrow, and the indications must be strictly controlled. Currently, only about 3% to 5% of patients can receive thrombolytic therapy. Therefore, neuroprotection has become an important part of the treatment of ischemic stroke, which is direc...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61P9/10A61P9/04
Inventor 蒋王林纪云霞
Owner BINZHOU MEDICAL COLLEGE
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